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Merck

D125806

N,N-Diisopropylethylamine

≥99%, liquid, ReagentPlus®

Synonym(s):

N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine, Hünig’s base

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About This Item

Linear Formula:
[(CH3)2CH]2NC2H5
CAS Number:
7087-68-5
Molecular Weight:
129.24
NACRES:
NA.21
PubChem Substance ID:
329798682
UNSPSC Code:
12352100
EC Number:
230-392-0
MDL number:
MFCD00008868
Assay:
≥99%
Form:
liquid

Key Documents

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Product Name

N,N-Diisopropylethylamine, ReagentPlus®, ≥99%

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

SMILES string

CCN(C(C)C)C(C)C

vapor pressure

31 mmHg ( 37.7 °C)

product line

ReagentPlus®

assay

≥99%

form

liquid

refractive index

n20/D 1.414 (lit.)

bp

127 °C (lit.)

mp

<−50 °C (lit.)

density

0.742 g/mL at 25 °C (lit.)

Quality Level

200

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General description

N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions. It acts as an activator for chiral iridium N, P ligand complexes, which can be utilized in the hydrogenation of α, β-unsaturated nitriles. The influence of varying concentration of N,N-diisopropylethylamine on the synthesis of olvanil in the presence of lipase catalyst has been investigated.

Application

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.
Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.1 °F

flash_point_c

9.5 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 1 petroleums + Hazardous rank II + Water insoluble liquid

fsl

D125806-5G: + D125806-2.5L: + D125806-BULK: + D125806-500G: + D125806-50L: + D125806-25KG: + D125806-500ML: + D125806-4X100ML: + D125806-5L: + D125806-VAR: + D125806-25L: + D125806-100G: + D125806-10L: + D125806-1L: + D125806-5KG: + D125806-5ML: + D125806-100ML:

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Certificates of Analysis (COA)

Lot/Batch Number
STBK8648
STBK7225
SHBP0407
STBK4951
STBK4094

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Synthetic Communications, 23, 3073-3073 (1993)
The Journal of Organic Chemistry, 58, 7162-7162 (1993)
The Journal of Organic Chemistry, 58, 1538-1538 (1993)
The Journal of Organic Chemistry, 59, 695-695 (1994)
Lipase-catalysed synthesis of olvanil in organic solvents.
Reyes-Duarte D, et al.
Biotechnology Letters, 24(24), 2057-2061 (2002)
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