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Merck

N1892

Nadolol

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C17H27NO4
CAS Number:
42200-33-9
Molecular Weight:
309.40
NACRES:
NA.24
PubChem Substance ID:
329818591
UNSPSC Code:
41116107
EC Number:
255-706-3
MDL number:
MFCD00079476

Key Documents

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InChI key

VWPOSFSPZNDTMJ-UCWKZMIHSA-N

InChI

1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1

SMILES string

CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

100

Gene Information

human ... ADRB1(153), ADRB2(154)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

β-Adrenergic blocker

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

N1892-10G: + N1892-1G: + N1892-5G: + N1892-VAR: + N1892-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6502
BCCC7386
BCBZ8568
BCBW2983
BCBD7864

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Priya Chockalingam et al.
Journal of the American College of Cardiology, 60(20), 2092-2099 (2012-10-23)
The purpose of this study was to compare the efficacy of beta-blockers in congenital long QT syndrome (LQTS). Beta-blockers are the mainstay in managing LQTS. Studies comparing the efficacy of commonly used beta-blockers are lacking, and clinicians generally assume they
Sarah Maud Fischer et al.
The Journal of pharmacy and pharmacology, 63(8), 1022-1030 (2011-07-02)
The aim of this study was to determine the influence of nonionic surfactants on drug permeability using the phospholipid vesicle-based permeation assay (PVPA), which excludes other than trans-membrane diffusion pathways. Barrier integrity was monitored both by electrical resistance and permeability
Wai Gin Lee et al.
Metabolism: clinical and experimental, 61(11), 1547-1553 (2012-05-09)
Elevated resting energy expenditure (REE) is seen in liver cirrhosis and is associated with reduced transplant-free survival. Non-selective β-blockers reduce REE in acute hypermetabolic conditions. We examined whether non-selective β-blockers reduce REE in patients with stable liver cirrhosis. Twenty-two stable
Sarah Maud Fischer et al.
International journal of pharmaceutics, 422(1-2), 52-58 (2011-10-27)
The compatibility of fasted state simulated intestinal fluid (FaSSIF) in drug permeation studies employing the phospholipid vesicle-based permeation assay (PVPA) model was confirmed by a set of different integrity indicators. Neither calcein permeability nor electrical resistance were found significantly changed
Elad Neeman et al.
Brain, behavior, and immunity, 26(2), 267-276 (2011-10-04)
Stress responses are known to modulate leukocyte trafficking. In the skin, stress was reported both to enhance and reduce skin immunity, and the chronicity of stress exposure was suggested as a key determining factor. We here propose a dual-stage hypothesis
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