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Merck

P8341

TWEEN® 20

Low-peroxide; Low-carbonyls

Synonym(s):

Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate

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About This Item

CAS Number:
9005-64-5
UNSPSC Code:
12161900
NACRES:
NA.21
MDL number:
MFCD00165986

Key Documents

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description

non-ionic

form

viscous liquid

Quality Level

200

impurities

≤0.5 μmol/g Peroxides, ≤1.0 μmol/g Carbonyls, ≤3.0% water

refractive index

n20/D 1.468 (lit.)

CMC

0.06 mM (20-25°C)

transition temp

cloud point 76 °C

density

1.1 g/cm3 at 25 °C (lit.)

HLB

16.7

storage temp.

−20°C

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General description

Tween®20, is a polyoxyethylene sorbitol ester that belongs to the polysorbate family. It is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid. The ethylene oxide subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment. Sorbitol forms the backbone ring to which the ethylene oxide polymers are attached.

Application

Non-ionic detergent
TWEEN 20 is widely used in several biochemical applications. It has been used:
  • As an emulsifying agent for the preparation of stable oil-in-water emulsions
  • In pre-extraction of membranes to remove peripheral proteins (used at 2% for extraction of membrane-bound proteins)
  • As a blocking agent for membrane based immunoassays at a typical concentration of 0.05%
  • For lysing mammalian cells at a concentration of 0.005 to 0.5%

Other Notes

Preservative Free

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

527.0 °F - Pensky-Martens closed cup

flash_point_c

275 °C - Pensky-Martens closed cup

ppe

Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P8341-VAR: + P8341-50ML: + P8341-10ML: + P8341-5X10ML: + P8341-100ML: + P8341PROC: + P8341-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL4400
SLCJ5811
SLCG6799
SLCF8551
SLCD8423

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Martindale: The Extra Pharmacopoeia, 1030-1030 null
The role of transforming growth factor beta isoforms in tendon-to-bone healing
Kim H M, et al.
Connective tissue research, 52(2), 87-98 (2011)
Detergents: an overview.
J M Neugebauer
Methods in enzymology, 182, 239-253 (1990-01-01)
M Hultdin et al.
Nucleic acids research, 26(16), 3651-3656 (1998-08-01)
Determination of telomere length is traditionally performed by Southern blotting and densitometry, giving a mean telomere restriction fragment (TRF) value for the total cell population studied. Fluorescence in situ hybridization (FISH) of telomere repeats has been used to calculate telomere
Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways.
Kerwin BA
Journal of Pharmaceutical Sciences, 97(8), 2924-2935 (2008)
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