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Merck

PHR1275

Naphthalene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Naphthalene

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About This Item

Empirical Formula (Hill Notation):
C10H8
CAS Number:
91-20-3
Molecular Weight:
128.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823271
EC Number:
202-049-5
Beilstein/REAXYS Number:
1421310
MDL number:
MFCD00001742

Key Documents

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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1457083

vapor density

4.4 (vs air)

vapor pressure

0.03 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

978 °F

expl. lim.

5.9 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

218 °C (lit.)

mp

80-82 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

c1ccc2ccccc2c1

InChI

1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H

InChI key

UFWIBTONFRDIAS-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Naphthalene is produced from fossil fuels such as coal and petroleum. Its commercial applications include, the production of polyvinyl plastics, moth repellents, dyes, leather tanning agents, resins, etc.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0011 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Flam. Sol. 2

Storage Class

4.1B - Flammable solid hazardous materials

wgk

WGK 3

flash_point_f

173.3 °F - closed cup

flash_point_c

78.5 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

PHR1275-1G-PW: + PHR1275-1G:4548173367439

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Toxicological Profile for Naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene (2005)
Fabrice Gritti et al.
Journal of chromatography. A, 1352, 20-28 (2014-06-14)
The effect of the pressure on the dispersion of a low molecular weight compound along 0.508 and 1.016 mm i.d. × 50 cm long open circular tubes was investigated theoretically and experimentally. The theoretical predictions were based on the early
A Buckpitt et al.
Drug metabolism reviews, 34(4), 791-820 (2002-12-19)
The lung, which is in intimate contact with the external environment, is exposed to a number of toxicants both by virtue of its large surface area and because it receives 100% of the cardiac output. Lung diseases are a major
Ralf Preuss et al.
International archives of occupational and environmental health, 76(8), 556-576 (2003-08-16)
For many years naphthalene had been considered as a non-carcinogenic polycyclic aromatic hydrocarbon (PAH). Airborne naphthalene concentrations have always been observed to be below the limit values of various national committees, such as the threshold limit value (TLV) of the
Martha L Bustos et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(3), 561-569 (2014-11-21)
The contribution of bone marrow cells (BMC) in lung repair is controversial. We previously reported a subpopulation of BMC that express Clara cell secretory protein (CCSP). To determine the contribution of endogenous CCSP(+) BMC to airway regeneration, we performed bone
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