Skip to Content
Merck

Key Documents

View All Documentation

PHR1292

Zidovudine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

3′-Azido-3′-deoxythymidine, AZT, Azidothymidine, ZDV, Zidovudine

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
30516-87-1
Molecular Weight:
267.24
MDL number:
MFCD00006536
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823283
Beilstein/REAXYS Number:
3595791
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Z1900000, traceable to USP 1724500

API family

zidovudine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

113-115 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

General description

Zidovudine (AZT) is a thymidine analog anti-HIV drug, known to decrease the mortality rate in patients affected with HIV. The mode of action involves inhibiting the activity of viral reverse transcriptase and interrupting HIV replication.

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

Zidovudine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, tablets and drug dosage forms by chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Reverse transcriptase inhibitor active against HIV-1 virus.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAA0303 in the slot below. This is an example certificate only and may not be the lot that you receive.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Still not finding the right product?

Explore all of our products under Zidovudine

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library