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Merck

S7920

Sodium fluoride

BioXtra, ≥99%

Synonym(s):

NaF, Natrium fluoride, Sodium monoflouride

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About This Item

Linear Formula:
NaF
CAS Number:
7681-49-4
Molecular Weight:
41.99
NACRES:
NA.25
PubChem Substance ID:
24899770
UNSPSC Code:
12352302
EC Number:
231-667-8
MDL number:
MFCD00003524
Assay:
≥99%
Solubility:
H2O: 1 M, clear, colorless

Key Documents

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InChI key

PUZPDOWCWNUUKD-UHFFFAOYSA-M

InChI

1S/FH.Na/h1H;/q;+1/p-1

SMILES string

[F-].[Na+]

vapor pressure

1.4 mmHg ( 0 °C)

product line

BioXtra

assay

≥99%

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

mp

993 °C (lit.)

solubility

H2O: 1 M, clear, colorless

anion traces

chloride (Cl-): ≤0.005%, sulfate (SO42-): ≤0.03%

cation traces

Al: ≤0.001%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.003%, K: ≤0.02%, Mg: ≤0.0005%, NH4+: ≤0.1%, Pb: ≤0.001%, Zn: ≤0.0005%

Quality Level

200

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Application

Sodium fluoride has been used:
  • as a source of fluoride ions, to analyse its impact on spermatogenesis and capacitation in vitro
  • as an additive in the extraction buffer for the isolation of nuclei, cytoplasmic and nuclear proteins
  • as a component of lysis buffer for the lysis of human ovarian adenocarcinoma OVCAR3 cells

Biochem/physiol Actions

Sodium fluoride (NaF) prevents dental caries, by catalysing the diffusion of calcium and phosphate and remineralizes the lesions. Fluoride affects spermatogenesis and capacitation process in the female reproductive tract. Fluoride induces oxidative stress, DNA damage in ovary ultimately affects the development of oocytes. Fluoride supplementation enhances bone mineral density. 18F-NaF is a radiotracer used in positron emission tomography (PET) to identify atherosclerotic lesions and other cardiac plaques.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

supp_hazards

EUH032

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Class I Designated Chemical Substances

prtr

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

S7920-BULK: + S7920-VAR: + S7920-100G:4548173951539 + S7920-500G:4548173951546

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Certificates of Analysis (COA)

Lot/Batch Number
SLCB1955
SLBT7421
SLBT7525
SLBP7726V
SLBK6350V

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Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice
Wang HW, et al.
Chemosphere, 186, 911-918 (2017)
Effects of treatment with fluoride on bone mineral density and fracture risk-a meta-analysis
Vestergaard P, et al.
Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 19(3), 257-268 (2008)
Dental caries
Selwitz RH, et al.
Lancet, 369(9555), 51-59 (2007)
Merging high-quality biochemical fractionation with a refined flow cytometry approach to monitor nucleocytoplasmic protein expression throughout the unperturbed mammalian cell cycle
Rosner M, et al.
Nature Protocols, 8(3), 602-602 (2013)
18F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis
Kitagawa T, et al.
Atherosclerosis, 263(3), 385-392 (2017)
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