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04273

Sodium phosphate dibasic dodecahydrate

meets analytical specification of Ph. Eur., BP, E339, 98.5-102.5% (T)

Synonym(s):

sec-Sodium phosphate, Disodium hydrogen phosphate dodecahydrate, Disodium phosphate, di-Sodium hydrogen phosphate dodecahydrate

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About This Item

Linear Formula:
Na2HPO4 · 12H2O
CAS Number:
10039-32-4
Molecular Weight:
358.14
PubChem Substance ID:
329747907
UNSPSC Code:
12161700
NACRES:
NA.25
EC Number:
231-448-7
MDL number:
MFCD00149181
Assay:
98.5-102.5% (T)
Form:
crystals
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Quality Level

200

agency

meets analytical specifications of BP, meets analytical specifications of Ph. Eur.

assay

98.5-102.5% (T)

form

crystals

quality

meets analytical specification of Ph. Eur., BP, E339

impurities

reducing matter, complies, residual solvents, complies, ≤0.001% heavy metals (as Pb), ≤1.0% NaH2PO4, 57-61% water (Karl Fischer)

loss

57-61% loss on drying

pH

8.4-9.6 (20 °C, 1%)

anion traces

chloride (Cl-): ≤10 mg/kg, fluoride (F-): ≤10 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg, Cd: ≤1 mg/kg, Cu: ≤20 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, K: ≤50 mg/kg, Pb: ≤4 mg/kg, Zn: ≤10 mg/kg

suitability

complies for appearance of solution

SMILES string

O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O

InChI

1S/2Na.H3O4P.12H2O/c;;1-5(2,3)4;;;;;;;;;;;;/h;;(H3,1,2,3,4);12*1H2/q2*+1;;;;;;;;;;;;;/p-2

InChI key

DGLRDKLJZLEJCY-UHFFFAOYSA-L

Application


  • Study of the Influence of Alkalizing Components on Matrix Pellets Prepared by Extrusion/Spheronization: This publication examines the effects of sodium phosphate dibasic dodecahydrate as an alkalizing agent in matrix pellets, showcasing its application in improving the physicochemical properties of pellets, which are crucial for controlled drug delivery systems (Hamedelniel EI, Bajdik J, Kasa P Jr, Pintye-Hodi K, 2012).

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Matthew H Crouthamel et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(11), 2625-2632 (2013-08-24)
Elevated serum phosphate has emerged as a major risk factor for vascular calcification. The sodium-dependent phosphate cotransporter, PiT-1, was previously shown to be required for phosphate-induced osteogenic differentiation and calcification of cultured human vascular smooth muscle cells (VSMCs), but its
Matthew R Weir et al.
Journal of clinical hypertension (Greenwich, Conn.), 16(12), 875-882 (2014-10-21)
The effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure (BP) and osmotic diuresis- and intravascular volume reduction-related adverse events (AEs) were evaluated using pooled data from four placebo-controlled, phase 3 studies in patients with type 2
Luciano Candilio et al.
Heart (British Cardiac Society), 101(3), 185-192 (2014-09-26)
Remote ischaemic preconditioning (RIPC), using brief cycles of limb ischaemia/reperfusion, is a non-invasive, low-cost intervention that may reduce perioperative myocardial injury (PMI) in patients undergoing cardiac surgery. We investigated whether RIPC can also improve short-term clinical outcomes. One hundred and
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