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Merck

201154

Sodium fluoride

ACS reagent, ≥99%

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About This Item

Linear Formula:
NaF
CAS Number:
7681-49-4
Molecular Weight:
41.99
NACRES:
NA.21
PubChem Substance ID:
329751974
UNSPSC Code:
12352302
EC Number:
231-667-8
MDL number:
MFCD00003524
Assay:
≥99%
Grade:
ACS reagent
Form:
powder

Key Documents

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InChI key

PUZPDOWCWNUUKD-UHFFFAOYSA-M

InChI

1S/FH.Na/h1H;/q;+1/p-1

grade

ACS reagent

agency

suitable for EPA 300

vapor pressure

1.4 mmHg ( 0 °C)

assay

≥99%

form

powder

impurities

≤0.01 meq/g Titr. base, ≤0.02% insolubles, ≤0.03 meq/g Titr. acid, ≤0.1% sodium fluorosilicate

loss

≤0.3% loss on drying

mp

993 °C (lit.)

anion traces

chloride (Cl-): ≤0.005%, sulfate (SO42-): ≤0.03%, sulfite (SO32-): ≤0.005%

cation traces

Fe: ≤0.003%, K: ≤0.02%, heavy metals (as Pb): ≤0.003%

Quality Level

200

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General description

Sodium fluoride (NaF) is a metallic halide. It has been reported as dental caries preventive agent. It is the most widely employed chemical preservative for the preservation of glucose in blood. It has been reported to stabilize the hepatic microsomal glucose-6-P phosphohydrolase enzyme.

Application

Sodium fluoride may be employed as a fluorination agent in the synthesis of aromatic and aliphatic fluorides. It may be used to prepare the lysis buffer.
Sodium fluoride may be used as a fluorinating agent for chlorine-containing compounds via halogen-exchange reaction.
Starting material for solid state preparation of Na3MnF6 for further high pressure structural determination studies.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

supp_hazards

EUH032

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Class I Designated Chemical Substances

prtr

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

201154-500G:4548173216744 + 201154-VAR: + 201154-6X500G: + 201154-BULK: + 201154-5G:4548173216751 + 201154-100G:4548173216737

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP8538
MKCN1670
MKCM8713
MKCK6136
MKCK7428

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The effect on human dental caries of weekly oral rinsing with a sodium fluoride mouthwash: a final report.
Horowitz HS, et al.
Archives of Oral Biology, 16(6), 609-616 (1971)
A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and initial caries lesion development in orthodontic patients.
?gaard B, et al.
European Journal of Orthodontics, 28(1), 8-12 (2006)
Effectiveness of sodium fluoride as a preservative of glucose in blood.
Chan AY, et al.
Clinical Chemistry, 35(2), 315-317 (1989)
A J Lange et al.
The Journal of biological chemistry, 261(1), 101-107 (1986-01-05)
Stabilization and inhibition of hepatic microsomal glucose-6-P phosphohydrolase (EC 3.1.3.9) by F- requires the presence of Al3+ ions. At millimolar concentrations, reagent grade NaF inhibited glucose-6-P hydrolysis and protected the enzyme against inactivation induced by heat in the presence of
Synthesis of fluorides by metathesis with sodium fluoride.
Tullock CW and Coffman DD.
The Journal of Organic Chemistry, 25(11), 2016-2019 (1960)
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