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Merck

55460

Hydroxylamine hydrochloride

puriss. p.a., ACS reagent, ≥99.0% (RT)

Synonym(s):

Hydroxylammonium chloride

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About This Item

Linear Formula:
NH2OH · HCl
CAS Number:
Molecular Weight:
69.49
UNSPSC Code:
12352300
NACRES:
NB.24
PubChem Substance ID:
EC Number:
226-798-2
Beilstein/REAXYS Number:
3539763
MDL number:
Assay:
≥99.0% (RT)
Form:
powder or crystals
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Quality Segment

vapor pressure

0.001 hPa ( 50 °C)

grade

ACS reagent, puriss. p.a.

assay

≥99.0% (RT)

form

powder or crystals

technique(s)

inhibition assay: suitable

ign. residue

≤0.05% (as SO4)

pH

2.5-3.5 (25 °C, 50 mg/mL in H2O)

mp

155-157 °C (dec.) (lit.)

density

1.67 g/mL at 25 °C (lit.)

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg, heavy metals: ≤5 ppm (by ICP)

SMILES string

Cl.NO

InChI

1S/ClH.H3NO/c;1-2/h1H;2H,1H2

InChI key

WTDHULULXKLSOZ-UHFFFAOYSA-N

General description

Hydroxylamine hydrochloride (Hydroxylammonium chloride) is the hydrochloride salt of hydroxylamine. It participates in the synthesis of 1,2,4-oxadiazoles.

Application



  • Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs.: This study utilized hydroxylamine hydrochloride in mass spectrometry to analyze the extracellular matrix proteins in various mouse organs, offering insights into tissue-specific protein compositions (McCabe et al., 2023).


  • Analysis of extracellular metabolome by HS-SPME/GC-MS: Optimization and application in a pilot study to evaluate galactosamine-induced hepatotoxicity.: Hydroxylamine hydrochloride was employed in HS-SPME/GC-MS to optimize the analysis of extracellular metabolites, crucial for assessing hepatotoxic effects (Araújo et al., 2018).


  • Improved production and processing of ⁸⁹Zr using a solution target.: This research enhanced the production process of zirconium-89 with hydroxylamine hydrochloride, improving efficiency and yield for medical imaging applications (Pandey et al., 2016).


  • Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery.: The study used hydroxylamine hydrochloride to modify gold nanoparticles, improving their biocompatibility and effectiveness in siRNA delivery systems (Rahme et al., 2015).


  • Preparation and photocatalytic performance of Fe (III)-amidoximated PAN fiber complex for oxidative degradation of azo dye under visible light irradiation.: Hydroxylamine hydrochloride was used in the synthesis of Fe(III)-amidoximated PAN fibers, enhancing their photocatalytic degradation properties for environmental applications (Dong et al., 2010).


Biochem/physiol Actions

MAO inhibitor; inhibits platelet aggregation.


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signalword

Warning

target_organs

spleen

Storage Class

4.1A - Other explosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Group 5: Self-reactive substances + Hydroxylamine salts + Hazardous rank II + 2nd self-reactive materials

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

55460-500G:4.548173169453E12 + 55460-1KG:4.548173169446E12 + 55460-100G:4.548173169439E12

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