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Merck

74480

L-Norepinephrine hydrochloride

≥98.0% (sum of enantiomers, HPLC)

Synonym(s):

L-Arterenol hydrochloride, L-Noradrenaline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
329-56-6
Molecular Weight:
205.64
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
57652452
EC Number:
206-345-5
Beilstein/REAXYS Number:
3916100
MDL number:
MFCD00064560
Assay:
≥98.0% (sum of enantiomers, HPLC)
Form:
crystals

Key Documents

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assay

≥98.0% (sum of enantiomers, HPLC)

form

crystals

optical activity

[α]20/D −38.5±5°, c = 2% in H2O

mp

~150 °C (dec.)

storage temp.

2-8°C

SMILES string

Cl[H].NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1

InChI key

FQTFHMSZCSUVEU-QRPNPIFTSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

Biochem/physiol Actions

Adrenal medullary stress hormone, mediator of the fight-or-flight response; and the primary neurotransmitter in the post-ganglionic sympathetic (adrenergic) nervous system.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

74480-BULK: + 74480-VAR: + 74480-1G: + 74480-100MG:

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Certificates of Analysis (COA)

Lot/Batch Number
1404775
1323912
070823/1
011570/1
11570/1

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The Laryngoscope, 124(5), E188-E193 (2013-10-12)
Noise generated by instruments, such as mastoid or craniotomy drills, may cause hearing damage by reducing the cochlear blood flow (CoBF). This study investigated whether dexmedetomidine can lessen noise-induced hearing loss (NIHL) in a guinea pig model. Animal study using
Wataru Inoue et al.
Nature neuroscience, 16(5), 605-612 (2013-04-09)
Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypothalamus
Sébastien Zanella et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(1), 36-50 (2014-01-02)
Neuronal networks are endogenously modulated by aminergic and peptidergic substances. These modulatory processes are critical for maintaining normal activity and adapting networks to changes in metabolic, behavioral, and environmental conditions. However, disturbances in neuromodulation have also been associated with pathologies.
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