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Merck

A2786

Adenine

BioReagent, suitable for cell culture

Synonym(s):

6-Aminopurine, Vitamin B4

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About This Item

Empirical Formula (Hill Notation):
C5H5N5
CAS Number:
73-24-5
Molecular Weight:
135.13
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
24890691
EC Number:
200-796-1
Beilstein/REAXYS Number:
5777
MDL number:
MFCD00041790

Key Documents

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Product Name

Adenine, BioReagent, suitable for cell culture

InChI key

GFFGJBXGBJISGV-UHFFFAOYSA-N

InChI

1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

SMILES string

Nc1ncnc2[nH]cnc12

biological source

synthetic

product line

BioReagent

assay

≥99%

form

powder

mol wt

Mw 135.13 g/mol

technique(s)

cell culture | mammalian: suitable

color

white to off-white

mp

>360 °C (lit.)

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

room temp

Quality Level

200

Gene Information

human ... AKT1(207), GSK3B(2932), LCK(3932), MAP3K1(4214), MAPK14(1432), MAPK8(5599), MAPK9(5601), MAPKAPK2(9261), PRKACA(5566), PRKCA(5578), RAF1(5894), ROCK2(9475)
mouse ... Mapk1(26413)
rat ... Camk2a(25400), Mapk10(25272)

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Application

Adenine has been used:
  • a component of green medium used for the derivation of keratinocytes from plucked hair follicles
  • for the serial culture of adult murine keratinocytes
  • as a media component for SSEA4+ limbal stromal stem cell differentiation

Biochem/physiol Actions

Adenine is a component of important biomolecules such as adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD). NAD and FAD forms the structure of DNA and RNA, and plays important role in protein synthesis. ATP is an energy source, that is essential for cellular respiration.

General description

Adenine is a purine nucleobase, synthesized from inosine monophosphate(IMP). It is a nitrogenous heterocyclic aromatic compound.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK2685
WXBD5261V
WXBD2576V
WXBD1877V
WXBD0910V

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The
Vander's Human Physiology, The Mechanisms of Body Function: Medicine, Human anatomy (2016)
Serial cultivation of primary adult murine keratinocytes
Epidermal Cells, 15-22 (2005)
Method for the Derivation of Induced Pluripotent Stem Cells from Human Hair Follicle Keratinocytes
Atlas of Human Pluripotent Stem Cells, 127-137 (2012)
Limbal stromal tissue specific stem cells and their differentiation potential to corneal epithelial cells
Embryonic Stem Cell Protocols, 437-444 (2015)
Brian T Wilhelm et al.
Nature protocols, 5(2), 255-266 (2010-02-06)
Next-generation sequencing technologies are revolutionizing genomics research. It is now possible to generate gigabase pairs of DNA sequence within a week without time-consuming cloning or massive infrastructure. This technology has recently been applied to the development of 'RNA-seq' techniques for
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