C0621
CI−994
≥98% (HPLC), HDAC Inhibitor, powder
Synonym(s):
4-Acetylamino-N-(2′-aminophenyl)benzamide, Acetyldinaline, Tacedinaline
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About This Item
Empirical Formula (Hill Notation):
C15H15N3O2
CAS Number:
Molecular Weight:
269.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
CI−994, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
DMSO: >10 mg/mL
storage temp.
room temp
SMILES string
CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N
InChI
1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
InChI key
VAZAPHZUAVEOMC-UHFFFAOYSA-N
Gene Information
Application
CI-994 has been used:
- as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effects
- as an HDAC inhibitor for screening in SPEL cells
- to study its effects on human myeloid and erythroid progenitors
Biochem/physiol Actions
CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994.
Orally available HDAC Inhibitor; CI-994 blocks cells in the G1-S phase of the cell cycle.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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