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Merck

C6445

Sodium cholate hydrate

BioXtra, ≥99%

Synonym(s):

3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C24H39NaO5 · xH2O
CAS Number:
206986-87-0
Molecular Weight:
430.55 (anhydrous basis)
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24892867
EC Number:
206-643-5
Beilstein/REAXYS Number:
3582354
MDL number:
MFCD00150749

Key Documents

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description

anionic

Quality Level

200

product line

BioXtra

assay

≥99%

form

powder

mol wt

micellar avg mol wt 900-1300

aggregation number

2-3

impurities

≤0.05% Phosphorus (P), ≤0.1% Insoluble matter

CMC

9-15 mM (20-25°C)

solubility

H2O: 1 M, clear, faintly yellow to yellow

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

HLB

18

application(s)

(Protein Solubilization and Purification)

SMILES string

O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C

InChI

1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1

InChI key

MUVVIYFKOVLQHL-RCVKHMDESA-M

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General description

Sodium cholate hydrate is a non-denaturing detergent used for the extraction of membrane proteins.

Application

Sodium cholate hydrate has been used:
  • as a component of biofilm growth media along with tryptic soy broth (TSB) to test the effects of each bile salt on biofilm formation
  • as a detergent to study its effect on cannabinoid receptor 1 (CB1) detection by western blot
  • as a promoter to prepare solution B for the synthesis of tungsten disulfide (WS2) on a SiO2/Si wafer

Sodium cholate hydrate has been used in a study to assess infiltration of pressurized promoter solutions in a mesoporous silica.

Features and Benefits

  • pH range 5-8
  • Suitable for membrane technology and culture media

hcodes

H412

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

C6445-BULK: + C6445-500G: + C6445-VAR: + C6445-100G: + C6445-1KG: + C6445-25G: + C6445-10G:

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F Peter Guengerich et al.
Nature protocols, 4(9), 1245-1251 (2009-08-08)
Cytochrome P450 (P450) enzymes are important in the metabolism of steroids, vitamins, carcinogens, drugs and other compounds. Two of the commonly used assays in this field are the measurements of total P450 and NADPH-P450 reductase in biological preparations. A detailed
Infiltration of pressurized promoter solutions in a mesoporous silica
Punyamurtula and Qiao
Microporous Mater., 103, 5-5 (2007)
Fang Fang et al.
Journal of bacteriology, 191(18), 5743-5757 (2009-07-14)
Commensal lactobacilli frequently produce bile salt hydrolase (Bsh) enzymes whose roles in intestinal survival are unclear. Twenty-six Lactobacillus salivarius strains from different sources all harbored a bsh1 allele on their respective megaplasmids. This allele was related to the plasmid-borne bsh1
Volkan K Köseoğlu et al.
Infection and immunity, 87(7) (2019-04-17)
Shigella flexneri is an intracellular bacterial pathogen that invades epithelial cells in the colonic mucosa, leading to bloody diarrhea. A previous study showed that S. flexneri forms biofilms in the presence of bile salts, through an unknown mechanism. Here, we
Thuc Hue Ly et al.
Nature communications, 7, 10426-10426 (2016-01-28)
Grain boundaries in monolayer transition metal dichalcogenides have unique atomic defect structures and band dispersion relations that depend on the inter-domain misorientation angle. Here, we explore misorientation angle-dependent electrical transport at grain boundaries in monolayer MoS2 by correlating the atomic
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