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Merck

C7806

Bovine Collagen Type II

from bovine nasal septum, powder, suitable for ELISA assays

Synonym(s):

Collagen from bovine

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About This Item

CAS Number:
9007-34-5
UNSPSC Code:
12352202
NACRES:
NA.61
EC Number:
232-697-4
MDL number:
MFCD00130825
Form:
powder
Biological source:
bovine nasal septum

Key Documents

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Product Name

Collagen from bovine nasal septum, Bornstein and Traub Type II, powder

biological source

bovine nasal septum

form

powder

technique(s)

ELISA: suitable

solubility

aqueous acid: soluble

UniProt accession no.

P02459

storage temp.

2-8°C

Quality Level

200

Gene Information

bovine ... COL2A1(407142)

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General description

Collagen is a fibrous protein, found in connective tissues, hard tissues, bone, dentin, cementum and also the mineralizing cartilage of the epiphyseal growth plate.
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen from bovine nasal septum has been used to coat the plates to estimate the levels of serum anti-cII IgG by enzyme-linked immunosorbent assay (ELISA). It has also been used as a component in the emulsified agent to induce arthritis in rats.
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type 2. Collagen-type 2 has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.

Biochem/physiol Actions

Collagen is the structural constituent of the dermis, which provides strength and support to the human skin. Variations in collagen participates in the aging process.

Preparation Note

An acid soluble collagen soluble in dilute acetic acid at pH 3.0 (5 mg/ml), yielding an opalescent, colorless solution.
Collagen Type II is a triple helix composed of three α1(II) strands.
Prepared by a modification of the pepsin extraction procedure of Niyibizi, et al., J. Biol. Chem., 259, 14170 (1984).

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

C7806-BULK: + C7806-VAR: + C7806-10MG: + C7806-5MG: + C7806-1MG:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK2783
SLCK8542
110M7002
110M7002V
038K3798

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Aging and the skin
Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 133-137 (2010)
Aspects of collagen mineralization in hard tissue formation
Wiesmann HP, et al.
International Review of Cytology, 242, 121-156 (2005)
The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats
Shi M, et al.
Journal of Inflammation, 12(1), 23-23 (2015)
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
Korganow AS, et al.
Immunity, 10(4), 451-461 (1999)
Rui Liu et al.
Therapeutic advances in chronic disease, 12, 2040622321991705-2040622321991705 (2021-05-18)
Evidence has demonstrated that non-coding RNAs (ncRNAs) could be delivered efficiently to recipient cells using exosomes as a carrier. Additionally, long ncRNA nuclear enriched abundant transcript 1 (NEAT1) is emerging as a vital regulatory molecule in the progression of rheumatoid
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