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Merck

D048

MPP+ iodide

≥98% (HPLC), ERα antagonist, powder

Synonym(s):

1-Methyl-4-phenylpyridinium iodide

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About This Item

Empirical Formula (Hill Notation):
C12H12IN
CAS Number:
36913-39-0
Molecular Weight:
297.13
UNSPSC Code:
12352200
PubChem Substance ID:
24893235
NACRES:
NA.77
MDL number:
MFCD00055096
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

MPP+ iodide, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

SMILES string

[I-].C[n+]1ccc(cc1)-c2ccccc2

InChI

1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1

InChI key

RFDFRDXIIKROAI-UHFFFAOYSA-M

Related Categories

General description

1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Application

MPP+ iodide has been used:
  • to induce oxidative stress in zebrafish embryos
  • for the inhibition of glutamate uptake in mitochondria of astrocytes
  • in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Biochem/physiol Actions

Active metabolite of dopaminergic neurotoxin MPTP
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Preparation Note

Solutions should be freshly prepared.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Photosensitive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

D048-BULK: + D048-1MG: + D048-100MG:4548173990415 + D048-VAR: + D048-1G:4548173990422

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Agnieszka Nikiforuk et al.
Frontiers in behavioral neuroscience, 11, 222-222 (2017-12-13)
Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter
JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss
Wang Q, et al.
Journal of Neuroinflammation, 15(1), 184-184 (2018)
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
Kalivendi SV, et al.
The Biochemical Journal, 371(1), 151-164 (2003)
Xi Yang et al.
Antimicrobial agents and chemotherapy, 60(10), 6260-6270 (2016-08-10)
Entecavir (ETV) is a first-line antiviral agent for the treatment of chronic hepatitis B virus infection. Renal excretion is the major elimination path of ETV, in which tubular secretion plays the key role. However, the secretion mechanism has not been
Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death
Sun L, et al.
Scientific Reports, 8(1), 383-383 (2018)
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