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Merck

D2158

Histodenz™

nonionic density gradient medium

Synonym(s):

5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide

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About This Item

Empirical Formula (Hill Notation):
C19H26I3N3O9
CAS Number:
66108-95-0
Molecular Weight:
821.14
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24893646
EC Number:
266-164-2
Beilstein/REAXYS Number:
2406632
MDL number:
MFCD00077732

Key Documents

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InChI key

NTHXOOBQLCIOLC-UHFFFAOYSA-N

InChI

1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)

SMILES string

CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I

form

powder

application(s)

hematology
histology

storage temp.

room temp

Quality Level

200

Related Categories

Application

HistoDenz™ is suitable for separating everything from macromolecules to viable cells by either rate-zonal or isopycnic centrifugation.
  • It has been used in the isolation and culturing of hepatic stellate cells.
  • It has also been employed in the extraction of microbial cells from environmental samples.
  • It has been used in LacZ (β-galactosidase) staining.
  • It has also been used for the enrichment of gonocytes.

Features and Benefits

HistoDenz™ offers several favorable properties as a gradient medium.
  • It has very low toxicity, low osmolality, high density, and low viscosity (compared to sucrose).
  • It is water-soluble, non-ionic, and chemically near-inert.

General description

HistoDenz™, also known as iohexol, is a non-ionic X-ray contrast compound developed specifically as an iodinated density gradient medium.

Legal Information

Histodenz is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

D2158-5G: + D2158-VAR: + D2158-BULK: + D2158-25G: + D2158-100G:4548173990507

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD6617V
WXBD5584V
WXBD3838V
WXBD1108V
WXBD2400V

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Extraction of Microbial Cells from Environmental Samples for FISH Approaches
Jennifer Pratscher
Methods in Molecular Biology, 2246 (2021)
Attachment of Pseudomonas putida onto differently structured kaolinite minerals: A combined ATR-FTIR and 1H NMR study.
Vasiliadou I A, et al.
Colloids and Surfaces. B, Biointerfaces, 84(2), 354-359 (2011)
Malin Helenius et al.
Scandinavian journal of urology, 49(5), 377-381 (2015-03-21)
Computed tomography urography (CTU) can be used to direct further investigation of patients if the bladder tumour detection rate is high. The aim of this study was to compare a CTU protocol including an enhancement-triggered scan and flexible cystoscopy for
Skeletal muscle tissue clearing for lacz and fluorescent reporters, and immunofluorescence staining.
Verma M, et al.
Methods in Molecular Biology, 129-140 (2016)
Optimization of culture conditions for short-term maintenance, proliferation, and colony formation of porcine gonocytes.
Awang-Junaidi, et al.
Journal of Animal Science and Biotechnology, 9(1), 8-8 (2018)
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Centrifugation enables the separation of particles by sedimentation. Learn how to separate particles using a centrifuge and how to use Stokes' law to calculate the velocity of sedimentation.

遠心分離の基礎

遠心分離は、沈降作用により粒子の分離を可能にします。遠心により粒子を分離する方法と、ストークスの法則を利用して沈降速度を計算する方法を説明します。

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