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Merck

D8161

1,4-Dithioerythritol

BioReagent, Molecular Biology, ≥99.0%

Synonym(s):

erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE

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About This Item

Linear Formula:
HSCH2CH(OH)CH(OH)CH2SH
CAS Number:
6892-68-8
Molecular Weight:
154.25
UNSPSC Code:
12161504
NACRES:
NA.31
PubChem Substance ID:
24894196
EC Number:
229-998-8
Beilstein/REAXYS Number:
1719756
MDL number:
MFCD00063750

Key Documents

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Product Name

1,4-Dithioerythritol, BioReagent, Molecular Biology, ≥99.0%

InChI key

VHJLVAABSRFDPM-ZXZARUISSA-N

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+

SMILES string

O[C@@H](CS)[C@H](O)CS

grade

Molecular Biology

product line

BioReagent

assay

≥99.0%

form

powder

reaction suitability

reagent type: reductant

pH

4.5-6.5 (25 °C, 15.4 g/L)

mp

82-84 °C (lit.)

solubility

water: 50 mg/mL

foreign activity

DNase, Exonuclease detection, RNase, and protease, none detected

storage temp.

2-8°C

Quality Level

200

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Related Categories

Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.
reducing reagent

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

D8161-VAR: + D8161-25G: + D8161-50G: + D8161-250MG: + D8161-1G: + D8161-5G: + D8161-10G: + D8161-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL0598
SLCH2034
SLCD6885
SLCB1393
SLBZ5002

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I Fialka et al.
Electrophoresis, 18(14), 2582-2590 (1998-04-04)
Protein targeting and sorting is accomplished by complex vesicular transport processes that are tightly regulated within a cell. This is especially important for epithelial cells because correct delivery of newly synthesized proteins as well as recycling and sorting of internalized
C Pasquali et al.
Electrophoresis, 18(14), 2573-2581 (1998-04-04)
Electrophoretic techniques, and especially two-dimensional gel electrophoresis (2-DE), have provided an indispensable set of tools for the separation of complex protein mixtures as well as for the identification of protein-protein interactions. Nevertheless, after its introduction more than twenty years ago
Tanju Ceyhan et al.
Dalton transactions (Cambridge, England : 2003), 39(41), 9801-9814 (2010-09-18)
The phthalodinitrile derivative 3 was prepared by the reaction of 1,4-dithioerythritol 1 and 4-nitrophthalonitrile 2 in dry DMF as the solvent in the presence of K(2)CO(3) as the base by the method of nucleophilic substitution of an activated nitro group
Magali Wagner et al.
Journal of agricultural and food chemistry, 59(7), 3146-3154 (2011-03-05)
During pasta processing, structural changes of protein occur, due to changes in water content, mechanical energy input, and high temperature treatments. The present paper investigates the impact of successive and intense thermal treatments (high temperature drying, cooking, and overcooking) on
Mu-De Li et al.
Electrophoresis, 30(2), 388-395 (2009-02-11)
In this study, we describe the use of Tween 20-capped gold nanoparticles (AuNPs) as selective probes for the extraction of aminothiols from an aqueous solution. Tween 20 molecules noncovalently attached to the surface of AuNPs to form Tween 20-AuNPs were
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