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E0251

Estrone 3-sulfate sodium salt

Name: Estrone 3-sulfate sodium salt
Brand: SIGMA

synthetic (organic), ≥98% (TLC), Inactive estrogen, powder

Synonym(s):

1,3,5(10)-Estratrien-17-one 3-sulfate

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About This Item

Linear Formula:

C₁₈H₂₁O₅SNa

CAS Number:

438-67-5

Molecular Weight:

372.41

UNSPSC Code:

12352202

PubChem Substance ID:

24894364

NACRES:

NA.77

MDL number:

MFCD00070035

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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Product Name

Estrone 3-sulfate sodium salt, contains ~35% Tris as stabilizer

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥98% (TLC)

form

powder

contains

~35% Tris as stabilizer

technique(s)

inhibition assay: suitable

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H22O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1

InChI key

GQZNDBBLTDOIBE-DLEHHZMWSA-N

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Bioactive Small Molecules

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This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Package size based on steroid content

pictograms

GHS08

signalword

Danger

hcodes

H351,H360,H362

pcodes

P202 - P260 - P263 - P264 - P270 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

E0251-25MG: + E0251-100MG-PW: + E0251-BULK: + E0251-VAR: + E0251-100MG: + E0251-1G-PW: + E0251-1G: + E0251-250MG: + E0251-500MG:

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Comparison of different regimens of estradiol benzoate treatments followed by long-acting progesterone to prepare noncycling mares as embryo recipients.

E S M Silva et al.

Theriogenology, 86(7), 1749-1756 (2016-08-09)

The present study evaluated the influence of different regimens of estradiol benzoate (EB) treatments followed by a single dose of long-acting progesterone (LA P4) on plasma estrogen and P4 concentrations in noncyclic mares prepared as embryo recipients. Twenty-one anestrous mares

Estrogen and androgen receptor expression in relation to steroid concentrations in the adult boar epididymis.

Christopher A Pearl et al.

Domestic animal endocrinology, 33(4), 451-459 (2006-10-13)

The steroid hormone regulation of the epididymis in a high estrogen producing animal like the boar is not currently understood. To test the hypothesis that the boar epididymis is an estrogen and androgen responsive tissue, the presence of estrogen and

Suppression of cell proliferation by inhibition of estrone-3-sulfate transporter in estrogen-dependent breast cancer cells.

Takashi Nozawa et al.

Pharmaceutical research, 22(10), 1634-1641 (2005-09-24)

The aim of the study is to suppress the progress of estrogen-dependent breast cancer by inhibiting the membrane transporter, which mediates the internalization of estrone-3-sulfate as estrogen precursor in the cancer cells. The uptake of estrone-3-sulfate by estrogen-dependent breast cancer

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Maria Karlgren et al.

Journal of medicinal chemistry, 55(10), 4740-4763 (2012-05-01)

The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models

Steroid hormones specifically modify the activity of organic anion transporting polypeptides.

Anna Koenen et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 774-780 (2012-09-18)

Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. However, it is unclear whether OATP2B1

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