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Merck

E1257

Epidermal Growth Factor from murine submaxillary gland

lyophilized powder, BioReagent, suitable for cell culture

Synonym(s):

EGF, Epidermal cell growth factor

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About This Item

CAS Number:
62229-50-9
UNSPSC Code:
12352202
EC Number:
263-468-7
NACRES:
NA.32
MDL number:
MFCD01634807

Key Documents

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biological source

mouse submaxillary glands

product line

BioReagent

assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

0.02-2.0 ng/mL EC50

packaging

pkg of 0.1 mg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

UniProt accession no.

P01132

storage temp.

2-8°C

Quality Level

200

Gene Information

mouse ... Egf(13645)

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Analysis Note

The biological activity is measured in a proliferation assay using BALB/MK cells.

Application

Epidermal Growth Factor from murine submaxillary gland has been used
  • in studying its effects on the development of caustic esophageal stricture in rats
  • for preparation of MCF-10A cell line
  • for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF)

Biochem/physiol Actions

Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation. EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes. It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia. EGF plays a major role in the maintenance of hair and skin development.

General description

Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor. It is majorly expressed in kidney, parotid gland and salivary gland.

Physical form

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

Preparation Note

Purified by gel filtration and ion-exchange chromatography.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

E1257-.1MG-PW: + E1257-BULK: + E1257-.1MG: + E1257-VAR:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM3791
SLCL7968
SLCJ7760
SLCJ0742
SLCJ0096

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Subcellular localization of epidermal growth factor receptor in human submandibular gland
Lantini MS, et al.
Journal of Anatomy, 208(5), 595-599 (2006)
High-sensitivity TFA-free LC-MS for profiling histones
You J, et al.
Proteomics, 11(16), 3326-3334 (2011)
Expression of epidermal growth factor in human tissues
Kajikawa K, et al.
Virchows Archiv. A, Pathological Anatomy and Histopathology, 418(1), 27-32 (1991)
Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats
Koltuksuz U, et al.
Journal of Pediatric Surgery, 36(10), 1504-1509 (2001)
Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway
Zhang H, et al.
Biochimie, 127(21), 10-18 (2016)
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