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Merck

G1796

Glycolide

≥99%

Synonym(s):

1,4-Dioxane-2,5-dione

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About This Item

Empirical Formula (Hill Notation):
C4H4O4
CAS Number:
502-97-6
Molecular Weight:
116.07
NACRES:
NA.23
PubChem Substance ID:
329799848
UNSPSC Code:
12162002
EC Number:
207-954-9
MDL number:
MFCD00081108

Key Documents

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InChI key

RKDVKSZUMVYZHH-UHFFFAOYSA-N

InChI

1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2

SMILES string

O=C1COC(=O)CO1

assay

≥99%

mp

82-86 °C (lit.)

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Related Categories

General description

Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.

Application

Glycolide can be used as a monomer in the preparation of poly(lactic-co-glycolide)(PGLA) via copolymerization with lactide monomer. PGLA is further used in the following applications:
  • Porous PGLA microsphere scaffolds are used in bone repair applications.
  • Encapsulated PGLA nanoparticles can be used in drug delivery and tissue engineering applications. Polymeric micro/nanoparticles made from PLGA have gained significant interest for their appealing characteristics, including biodegradability, biocompatibility, prolonged drug release, and safeguarding the drug against degradation.
It can also be used to synthesize poly(glycolide-caprolactone)(PGCL) copolymers applicable as bioabsorbable suture materials.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

G1796-BULK: + G1796-25G: + G1796-VAR:

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Towards electroactive gel artificial muscle structures
Electroactive Polymer Actuators and Devices (EAPAD) XX, 10594, 1059408-1059408 (2018)
Types of biodegradable polymers
Introduction of Bioplastic Engineering, 81-151 (2016)
J L Guo et al.
Science advances, 5(6), eaaw7396-eaaw7396 (2019-06-12)
Synthetic hydrogels are investigated extensively in tissue engineering for their tunable physicochemical properties but are bioinert and lack the tissue-specific cues to produce appropriate biological responses. To introduce tissue-specific biochemical cues to these hydrogels, we have developed a modular hydrogel
Zohreh Arabpour et al.
Journal of biomedical materials research. Part A, 107(10), 2340-2349 (2019-06-05)
Tissue engineering is one of the most promising areas for treatment of various ophthalmic diseases particularly for patients who suffer from limbal stem cell deficiency and this is due to the lack of existence of appropriate matrix for stem cell
Yutong Han et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(15), 1900251-1900251 (2019-08-14)
Due to specific immune recognition receptors on the surface of T cells, their membranes are promising mimic nanocarriers for delivering drugs to tumor lesions. However, this single targeting strategy potentially compromises therapy efficacy for tumor targeting due to inter- and
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