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Merck

H0915

Hydroxychloroquine sulfate

≥98% (HPLC), powder, anti-inflammatory

Synonym(s):

Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate

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About This Item

Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
747-36-4
Molecular Weight:
433.95
NACRES:
NA.77
PubChem Substance ID:
329815141
UNSPSC Code:
12352200
EC Number:
212-019-3
MDL number:
MFCD00078203

Key Documents

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Product Name

Hydroxychloroquine sulfate, ≥98% (HPLC), powder

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to off-white

solubility

H2O: >20 mg/mL

Quality Level

100

Gene Information

human ... TLR7(51284), TLR9(54106)

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Application

Hydroxychloroquine sulfate has been used:
  • as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line
  • to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay
  • to inhibit lysosome fusion with the autophagosome

Biochem/physiol Actions

Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor.
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
046M4758V
074M4735V
043M4750V
022M4749V
110M4711V

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Barry Ladizinski et al.
Journal of the American Academy of Dermatology, 68(5), 749-755 (2013-02-05)
Frontal fibrosing alopecia (FFA) is a type of scarring hair loss primarily observed in postmenopausal women and characterized by fronto-tempero-parietal hairline recession, perifollicular erythema, and loss of eyebrows. The incidence is unknown, but the number of women presenting with this
Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells
Li K, et al.
Biochemical and Biophysical Research Communications, 460(2), 380-385 (2015)
The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells
Schott CR, et al.
Testing, 13(10), e0206427-e0206427 (2018)
Pharmacotherapeutics for Advanced Practice, 536, 435-435 (2006)
Fluorescence Microscopy Analysis of Drug Effect on Autophagosome Formation
Stankov M, et al.
Antimicrobial agents and chemotherapy (2013)
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