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Merck

H9039

Hemin

from bovine, ≥90%

Synonym(s):

Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride)

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About This Item

Empirical Formula (Hill Notation):
C34H32ClFeN4O4
CAS Number:
16009-13-5
Molecular Weight:
651.94
UNSPSC Code:
12352202
NACRES:
NA.61
PubChem Substance ID:
329815257
EC Number:
240-140-1
Beilstein/REAXYS Number:
5229914
MDL number:
MFCD00010726

Key Documents

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Product Name

Hemin, from bovine, ≥90%

InChI

1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

SMILES string

Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Fe](Cl)n34)c(C=C)c5C

InChI key

BTIJJDXEELBZFS-HXFTUNQESA-K

biological source

bovine

assay

≥90%

form

powder

technique(s)

toxicology assay: suitable

solubility

1.4 M NH4OH: soluble 25 mg/mL

storage temp.

2-8°C

Quality Level

200

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Application

Hemin was used to study conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis.

General description

Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe2+ ion called hemin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ2236
SLCG8023
SLCC3454
SLBZ9535
SLBZ9649

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Murat Topuzogullari et al.
Journal of biomedical science, 20, 35-35 (2013-06-05)
Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to classical adjuvants. For example, polyacrylic acid (PAA) is a weak polyelectrolyte
Post-embryonic development in Caenorhabditis elegans.
D L Riddle
International journal for parasitology, 17(1), 223-231 (1987-02-01)
Rodgoun Attarian et al.
mBio, 9(6) (2018-12-06)
The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus Cryptococcus neoformans In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in C.
Xiaoyu Shi et al.
Molecular microbiology, 114(3), 454-467 (2020-05-21)
Reticulon and REEP family of proteins stabilize the high curvature of endoplasmic reticulum (ER) tubules. Plasmodium berghei Yop1 (PbYop1) is a REEP5 homolog in Plasmodium. Here, we characterize its function using a gene-knockout (Pbyop1∆). Pbyop1∆ asexual stage parasites display abnormal
Alistair Harrison et al.
Cell reports, 30(9), 2978-2988 (2020-03-05)
Bacteria adapt to dynamic changes in the host during chronic and recurrent infections. Bacterial microevolution is one type of adaptation that imparts a selective advantage. We hypothesize that recurrent episodes of disease promote microevolution through genetic mutations that modulate disease
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