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H9411

Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit

Name: Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AHO3, Anti-BDMR, Anti-HA6116, Anti-HD4, Anti-HDAC-4, Anti-HDAC-A, Anti-HDACA

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03791601

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IF, IP, WB

Citations:

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Properties

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~140 kDa (additional weaker bands may be present)

species reactivity

rat, human, mouse

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunoprecipitation (IP): 10-20 μg using RIPA extract of HeLa nuclei, indirect immunofluorescence: 1:250 using HeLa cells, microarray: suitable, western blot: 1:1,000 using whole extracts of mouse NIH3T3 cells, western blot: 1:500 using whole extracts of rat brain

UniProt accession no.

P56524

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HDAC4(9759)
mouse ... Hdac4(208727)
rat ... Hdac4(363287)

Description

General description

Mammalian histone deacetylases (HDACs) can be divided into three classes according to sequence homology. Class II consists of the yeast Hda1-like proteins histone deacetylase 4,5,6,7,8,9, 10 (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10.

Immunogen

synthetic peptide corresponding to amino acid residues 1-19 of human HDAC4 with C-terminal added lysine conjugated to KLH.

Application

Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit has been used in:

immunoblotting
immunoprecipitation
immunofluorescence
immunostaining
immunohistochemistry
chromatin immunoprecipitation

Biochem/physiol Actions

Histone deacetylase 4 (HDAC4) exhibits intrinsic nuclear import and export signals for its dynamic nucleocytoplasmic shuttling. Its association with 14-3-3 and monocyte enhancer factor 2 (MEF2) proteins can disturb shuttling and thus directs HDAC4 to the cytoplasm and the nucleus, respectively.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

H9411-VAR: + H9411-200UL: + IXO11342: + H9411-BULK:

jan

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Certificates of Analysis (COA)

Lot/Batch Number

082K4809

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