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Merck

I2018

Monoclonal Anti-Insulin antibody produced in mouse

clone K36AC10, ascites fluid

Synonym(s):

Insulin Antibody, Insulin Antibody - Monoclonal Anti-Insulin antibody produced in mouse

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00164675
Conjugate:
unconjugated
Clone:
K36AC10, monoclonal
Application:
DB, IHC (p), RIA
Species reactivity:
feline, human, rat, horse, rabbit, guinea pig, bovine, monkey, sheep, canine, pig
Citations:
138
Technique(s):
dot blot: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human or animal pancreas, radioimmunoassay: suitable
Uniprot accession no.:
P01308

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

K36AC10, monoclonal

contains

15 mM sodium azide

species reactivity

feline, human, rat, horse, rabbit, guinea pig, bovine, monkey, sheep, canine, pig

technique(s)

dot blot: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human or animal pancreas, radioimmunoassay: suitable

isotype

IgG1

UniProt accession no.

P01308

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... INS(3630)

Related Categories

Application

Monoclonal Anti-Insulin antibody produced in mouse has been used in immunoblotting assay and ELISA.
Monoclonal Anti-Insulin antibody produced in mouse was used in ELISA-based protein pin array assay to study the interactions between human αB crystalline and insulin. It was used for flow cytometric analysis of rat white blood cells and mast cells.

Biochem/physiol Actions

Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways.
Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways. Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. Insulin is known to stimulate cell division.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The antibody reacts specifically against insulin by RIA and immunocytochemistry. It exhibits cross-reactivity with human proinsulin. The antibody binds to insulin with an affinity constant of 8.8 × 109 M-1 in RIA.
The insulin gene is mapped to human chromosome 11p15.5.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

I2018-.2ML: + I2018-VAR: + I2018-100UL: + I2018-BULK: + I2018-.5ML:

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Certificates of Analysis (COA)

Lot/Batch Number
099M4873V
22190413
098M4869V
22180618
018M4754V

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Sandra K Szlapinski et al.
The Journal of physiology, 597(16), 4237-4250 (2019-06-18)
Pancreatic β-cell dysfunction is hypothesized to be the significant determinant of gestational diabetes pathogenesis, however pancreatic samples from patients are scarce. This study reports a novel mouse model of gestational glucose intolerance in pregnancy, originating from previous nutrition restriction in
Lechago J and Shah I
Atlas of Diagnostic Immunochemistry null
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.
Wang F, et al.
Diabetes, 50(11), 2514-2520 (2001)
J Matthew Rhett et al.
Journal of diabetes research, 2016, 7262680-7262680 (2016-01-21)
Total pancreatectomy and islet autotransplantation is a cutting-edge technique to treat chronic pancreatitis and postoperative diabetes. A major obstacle has been low islet cell survival due largely to the innate inflammatory response. Connexin43 (Cx43) channels play a key role in
Proinsulin-specific monoclonal antibodies. Immunocytochemical application as beta-cell markers and as probes for conversion.
O D Madsen
Diabetes, 36(10), 1203-1211 (1987-10-01)
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