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Merck

I2644

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

IL-2, Interleukin-2, Interleukin-2 human, T-cell growth factor, hIL-2

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00165721
Biological source:
human
Recombinant:
expressed in E. coli
Form:
lyophilized powder
Mol wt:
15.5 kDa
Impurities:
≤1 EU/μg

Key Documents

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Product Name

Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in E. coli

form

lyophilized powder

potency

≤700 EC50

quality

endotoxin tested

mol wt

15.5 kDa

packaging

pkg of 5X10 μg, pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

P60568

storage temp.

−20°C

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General description

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Application

Interleukin-2 human has been used:
  • in the stimulation of natural killer cells
  • to study its ability to stimulate lymphocyte growth and prevent apoptosis
  • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

Biochem/physiol Actions

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized, 0.2 μm filtered, no additives.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

I2644-10UG: + I2644-VAR: + I2644-5X10UG: + I2644-BULK-N: + I2644PROC: + I2644-PH: + I2644-10UG-PW: + I2644-BULK:

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Loss of immune tolerance to IL-2 in type 1 diabetes
Perol L, et al.
Nature Communications, 7(2), 13027-13027 (2016)
Stefania Braidotti et al.
Frontiers in bioscience (Landmark edition), 27(2), 39-39 (2022-03-01)
The T-cell engager antibody blinatumomab (BlincytoT⁢M) represents a promising rescue therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab creates a tight synapsis between CD3+ T-lymphocytes and leukemic CD19+ B-cells
Interleukin 2, 37-37 (2012)
Culture methods for turtle lymphocytes
Ulsh BA, et al.
Methods in Cell Science : An Official Journal of the Society for In Vitro Biology, 22(4), 285-297 (2000)
Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype
Pridgeon C, et al.
Rheumatology (Basel), 42(7), 870-878 (2003)
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Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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