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I7379

Imipramine hydrochloride

≥99% (TLC), powder, selective serotonin reuptake inhibitor

Synonym(s):

10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H24N2 · HCl
CAS Number:
113-52-0
Molecular Weight:
316.87
NACRES:
NA.77
PubChem Substance ID:
24278097
UNSPSC Code:
12352116
EC Number:
204-030-7
MDL number:
MFCD00012669
Assay:
≥99% (TLC)
Form:
powder
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Product Name

Imipramine hydrochloride, ≥99% (TLC)

Quality Segment

assay

≥99% (TLC)

form

powder

color

white

solubility

H2O: 50 mg/mL

originator

Novartis

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Gene Information

General description

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.

Application

Imipramine hydrochloride has been used:
  • as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
  • to investigate its interaction with insulin in aqueous solution
  • to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with Kis of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (Ki = 25 μM).
Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters; has little effect on the dopamine transporter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Hazard Classifications

Acute Tox. 4 Oral

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

I7379-100G: + I7379-25G: + I7379-BULK: + I7379-VAR: + I7379-5G:

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