K8625
L-Kynurenine
≥98% (HPLC)
Synonym(s):
β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
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About This Item
Empirical Formula (Hill Notation):
C10H12N2O3
CAS Number:
Molecular Weight:
208.21
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
Product Name
L-Kynurenine, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
mp
219 °C
application(s)
detection
SMILES string
N[C@@H](CC(=O)c1ccccc1N)C(O)=O
InChI
1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1
InChI key
YGPSJZOEDVAXAB-QMMMGPOBSA-N
Application
L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.
Biochem/physiol Actions
L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. It is involved in a variety of neurological processes and diseases. L-Kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.
Key intermediate in the breakdown pathway of tryptophan.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Find documentation for the products that you have recently purchased in the Document Library.
The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease
Anna Zinger
Parkinson's Disease (2011)
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
Yiquan Chen
International Journal of Tryptophan Research : IJTR, 2, 1-19 (2009)
Essential and Non-Essential Metals Metabolites with Antibiotic Activity Pharmacology of Benzodiazepines Interferon Gamma Research (2012)