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Merck

L5647

Lidocaine hydrochloride monohydrate

≥99% (HPLC), solid, Na⁺ channel blocker

Synonym(s):

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate

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About This Item

Empirical Formula (Hill Notation):
C14H22N2O · HCl · H2O
CAS Number:
6108-05-0
Molecular Weight:
288.81
NACRES:
NA.77
PubChem Substance ID:
24277718
UNSPSC Code:
12352200
EC Number:
200-803-8
MDL number:
MFCD00150329
Form:
solid
Quality level:
200

Key Documents

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Product Name

Lidocaine hydrochloride monohydrate, solid

form

solid

Quality Level

200

color

white

solubility

H2O: soluble

SMILES string

Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2

InChI key

YECIFGHRMFEPJK-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Related Categories

General description

Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life.

Application

Lidocaine hydrochloride monohydrate has been used:
  • in the preparation of drug composite for the controlled delivery in vitro, evaluated by drug release profile in ultra-high performance liquid chromatography (UPLC) and as a reference standard for fourier transform infrared spectroscopy (FT-IR).
  • to record dose dependent response of sodium voltage (Nav1.7) channels in the injection-molded polymer device.
  • For inhibition of glial cells in brain tissue samples.

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration
Na+ channel blocker; class IB antiarrhythmic.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

L5647-VAR: + L5647-100G: + L5647-15G: + L5647-250G: + L5647-BULK:

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Certificates of Analysis (COA)

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Ion channel recordings on an injection-molded polymer chip
Tanzi S, et al.
Lab on a chip, 13(24), 4784-4793 (2013)
HIV-1 Tat-induced diarrhea evokes an enteric glia-dependent neuroinflammatory response in the central nervous system
Esposito G, et al.
Scientific Reports, 7(1), 7735-7735 (2017)
Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery
Dubnika A, et al.
Ceramics International, 43(4), 3698-3705 (2017)
Giovanni Sarnelli et al.
Journal of neuroinflammation, 15(1), 94-94 (2018-03-27)
Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activity.
Päivi Ylä-Anttila et al.
Methods in enzymology, 452, 143-164 (2009-02-10)
Electron microscopy remains one of the most accurate methods for the detection of autophagy and quantification of autophagic accumulation. Compared to fluorescence microscopy, the resolution of transmission electron microscopy is superior. In this chapter we describe the fine structure of
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