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Merck

M0880

Ethyl methanesulfonate

liquid

Synonym(s):

Ethyl mesylate, Methanesulfonic acid ethyl ester

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About This Item

Linear Formula:
CH3SO3CH2CH3
CAS Number:
62-50-0
Molecular Weight:
124.16
UNSPSC Code:
12352108
NACRES:
NA.25
PubChem Substance ID:
24896575
EC Number:
200-536-7
Beilstein/REAXYS Number:
773969
MDL number:
MFCD00007559

Key Documents

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InChI key

PLUBXMRUUVWRLT-UHFFFAOYSA-N

InChI

1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3

SMILES string

CCOS(C)(=O)=O

form

liquid

refractive index

n20/D 1.418 (lit.)

bp

85-86 °C/10 mmHg (lit.)

density

1.206 g/mL at 20 °C

Quality Level

200

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Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

212.0 °F

flash_point_c

100 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water insoluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

M0880-25G:4548173950006 + M0880-BULK: + M0880-VAR: + M0880-100G:4548173949970 + M0880-5G:4548173950013 + M0880-10G:4548173949987 + M0880-1G:4548173949994

jan

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1105
BCCF0900
BCCD0159
BCBZ8402
BCBW8635

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Novel wine yeast with ARO4 and TYR1 mutations that overproduce `floral?aroma compounds 2-phenylethanol and 2-phenylethyl acetate
Cordente AG, et al.
Applied Microbiology and Biotechnology, 1-12 (2018)
Scanning ethyl methanesulphonate effects on the whole genome of Lotus japonicus using second generation sequencing analysis
Mohd-Yusoff NF, et al.
G3 (Bethesda, Md.), g3-114 (2015)
Establishment of a human somatic hybrid cell line for recombinant protein production
Cho MS, et al.
Journal of Biomedical Science, 9(6), 631-638 (2002)
Genotoxicity Effect of Ethyl Methanesulfonate on Root Tip Cells of Chilli (Capsicum annuum L.)
Devi AS and Mullainathan L
World Journal of Agricultural Sciences, 7(4), 368-374 (2011)
In vitro mutation induction of Saintpaulia using ethyl methanesulfonate
Fang JY and Traore S
Hortscience: a Publication of the American Society For Horticultural Science Hortscience, 46(7), 981-984 (2011)
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