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N5254

Neuraminidase Agarose from Clostridium perfringens (C. welchii)

Type VI-A, ammonium sulfate suspension

Synonym(s):

Acylneuraminyl hydrolase, Receptor-destroying enzyme, Sialidase

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
3.2.1.18 (BRENDA, IUBMB)
MDL number:
MFCD00131711
Specific activity:
20-60 units/g agarose

Key Documents

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type

Type VI-A

form

ammonium sulfate suspension

specific activity

20-60 units/g agarose

extent of labeling

0.6-1.8 units per mL gel, 20-60 units per g agarose

matrix

beaded agarose

storage temp.

2-8°C

Quality Level

200

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Application

Agarose-linked neuraminidase from Clostridium perfringens can be used for the detection of total and desialylated sex hormone-binding globulin in human serum samples.
Neuraminidase from Clostridium perfringens has been used in a study to assess a genetic polymorphism of human serum glycoprotein (inter-α-trypsin-inhibitor). It has also been used in a study to investigate the inhibition of neuraminidase by chemically sulphated glycopeptides.

General description

Neuraminidase enzymes are glycoside hydrolase enzymes that catalyze hydrolysis of terminal sialic acid residues. The most well-known are the viral nearamidases, which promote influenza virus release.

Other Notes

One unit will liberate 1.0 μmole of N-acetylneuraminic acid per min at pH 5.0 at 37 °C using NAN-lactose or bovine submaxillary mucin, unless otherwise specified. Prices based on units using NAN-lactose as substrate.

Physical form

Suspension in 2.0 M (NH4)2SO4 solution, pH 7.0.

Preparation Note

Prepared from Neuraminidase, Type VI (N 3001).

Storage Class

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

N5254-1UN: + N5254-10UN: + N5254-BULK: + N5254-5UN: + N5254-VAR: + N5254-.5UN:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
128K5155V
SLBB3867
021M5154
128K5155
029H7836

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The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46
Arnon, T.I., et al
Immunobiol., 103(2), 664-672 (2004)
U Vogt et al.
Human genetics, 84(2), 151-154 (1990-01-01)
A new genetic polymorphism of a human serum glycoprotein, the inter-alpha-trypsin-inhibitor (ITI), has been demonstrated by population and family studies. Sera were examined after neuraminidase treatment by isoelectric focusing on agarose gels followed by immunoblotting or by immunofixation with specific
Measurements of total and desialylated sex hormone binding globulin in serum by ELISA.
J Vaysse et al.
Clinical chemistry, 44(4), 882-884 (1998-04-29)
N Mian et al.
The Biochemical journal, 181(2), 377-385 (1979-08-01)
Chemically sulphated glycopeptides (derived from pig duodenal mucosa) inhibited Clostridium perfringens neuraminidase (EC 3.2.1.18) activity in a pH-dependent manner. Analysis of inhibition kinetics data indicated that, although the enzyme inhibition could not be categorized into any of the classical types
T I Arnon et al.
European journal of immunology, 31(9), 2680-2689 (2001-09-06)
Natural killer (NK) cells destroy virus-infected and tumor cells without prior antigen stimulation. The NK cell cytotoxicity is regulated in large part by the expression of NK cell receptors that are able to bind major histocompatibility complex (MHC) class I
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