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Merck

N8161

NS309

≥98% (HPLC),  Ca2+-activated IK/SK potassium channel activator, solid

Synonym(s):

3-Oxime-6,7-dichloro-1H-indole-2,3-dione

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About This Item

Empirical Formula (Hill Notation):
C8H4Cl2N2O2
CAS Number:
18711-16-5
Molecular Weight:
231.04
UNSPSC Code:
12352200
PubChem Substance ID:
329818681
NACRES:
NA.77
MDL number:
MFCD06798346
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200

Key Documents

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Product Name

NS309, ≥98% (HPLC), solid

SMILES string

O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12

InChI key

CVOUSAVHMDXCKG-UHFFFAOYSA-N

InChI

1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: 22 mg/mL

storage temp.

2-8°C

Quality Level

200

Related Categories

Biochem/physiol Actions

NS309 is a Ca2+-activated IK/SK potassium channel activator.

Disclaimer

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Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

N8161-VAR: + N8161-BULK: + N8161-5MG: + N8161-25MG:

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Certificates of Analysis (COA)

Lot/Batch Number
BGBC3967
098K4623V
098K46232
098K46231
098K4623

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Pedarzani, P., et al.
Abstr. Soc. Neurosci, 367-367 (2003)
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
Fan-Fan Li et al.
Placenta, 58, 9-16 (2017-10-01)
Excessive constriction of placental chorionic plate arteries (CPAs) may be associated with preeclampsia (PE). Nitric oxide (NO) as well as intermediate and small Ca The location of IK IK This study provides evidence that dysregulated IK
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null
Abbie C Johnson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2857-2869 (2016-11-07)
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high
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