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Merck

P1639

Patulin

≥98.0% (HPLC)

Synonym(s):

Clavacin, Clavatin, Expansine, Gigantin, Leucopin, Mycoine C3, Terinin, 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one

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About This Item

Empirical Formula (Hill Notation):
C7H6O4
CAS Number:
149-29-1
Molecular Weight:
154.12
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
24898227
EC Number:
205-735-2
Beilstein/REAXYS Number:
149675
MDL number:
MFCD00005858

Key Documents

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Product Name

Patulin, ≥98.0% (HPLC)

InChI

1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2

InChI key

ZRWPUFFVAOMMNM-UHFFFAOYSA-N

SMILES string

OC1OCC=C2OC(=O)C=C12

assay

≥98.0% (HPLC)

form

powder

solubility

water: 9-11 mg/mL

antibiotic activity spectrum

fungi

mode of action

cell membrane | interferes

storage temp.

−20°C

Quality Level

300

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Application

Patulin has been used:
  • to study patulin contamination of bottled wine
  • in DNA-damaging activity of patulin in Escherichia coli
  • in molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus

Biochem/physiol Actions

Mycotoxin with anti-bacterial, potassium uptake inhibitory, and possibly carcinogenic activities. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking.

General description

Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It is commonly found in apples. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300,H315

Hazard Classifications

Acute Tox. 2 Oral - Skin Irrit. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
077M4094V
114M4000V
039M4040V
14180811
058M4075V

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Nikita Malhotra et al.
International journal of cardiology, 197, 318-325 (2015-07-08)
A therapeutic window in antiplatelet treatment has been associated with concurrent lowering of bleeding and ischemic risks. Prasugrel and ticagrelor provide potent platelet inhibition, but may increase bleeding. No study has evaluated a personalized therapy with selective use of novel
Birkinshaw, M., et al.
Lancet, 245, 625-625 (1943)
Effects of various lactones and related compounds on cation transfer in incubated cold-stored human erythrocytes.
J B KAHN
The Journal of pharmacology and experimental therapeutics, 121(2), 234-251 (1957-10-01)
Peter O Krutzik et al.
Nature chemical biology, 4(2), 132-142 (2007-12-25)
Drug screening is often limited to cell-free assays involving purified enzymes, but it is arguably best applied against systems that represent disease states or complex physiological cellular networks. Here, we describe a high-content, cell-based drug discovery platform based on phosphospecific
Alicia Rodríguez et al.
International journal of food microbiology, 155(1-2), 10-18 (2012-02-14)
A multiplex real-time PCR (qPCR) method to quantify aflatoxin, ochratoxin A (OTA) and patulin producing molds in foods was developed. For this, the primer pairs F/R-omt, F/R-npstr and F/R-idhtrb and the TaqMan probes, OMTprobe, NPSprobe and IDHprobe targeting the omt-1
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