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Merck

P3075

Phenylarsine oxide

synthetic (organic), ≥97%, tyrosine phosphatase inhibitor, powder

Synonym(s):

Arzene, Oxophenylarsine, PAO

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About This Item

Empirical Formula (Hill Notation):
C6H5AsO
CAS Number:
637-03-6
Molecular Weight:
168.02
NACRES:
NA.77
PubChem Substance ID:
24898387
UNSPSC Code:
12352119
EC Number:
211-275-3
MDL number:
MFCD00001990
Beilstein/REAXYS Number:
2935227

Key Documents

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Product Name

Phenylarsine oxide, ≥97%, powder

Quality Level

100

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

SMILES string

O=[As]c1ccccc1

biological source

synthetic (organic)

assay

≥97%

form

powder

color

white to off-white

mp

145-148 °C

solubility

DMSO: 50 mg/mL

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Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Biochem/physiol Actions

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.
Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Phenylarsine oxide (PhAsO4) is a bifunctional SH group chemical. It is hydrophobic in nature.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ0109
MKCM3203
MKCK5974
MKCJ0095
MKBZ4231V

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Inhibition of setaria cervi protein tyrosine phosphatases by phenylarsine oxide: A proteomic and biochemical study
Singh N, et al.
Acta Tropica, 159, 20-28 (2016)
Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria
Lenartowicz E, et al.
Journal of Bioenergetics and Biomembranes, 23(4), 679-688 (1991)
Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats
Lu X, et al.
Experimental neurology, 178(2), 259-267 (2002)
M Wachtel et al.
Journal of cell science, 112 ( Pt 23), 4347-4356 (1999-11-24)
Regulation of epithelial and endothelial permeability is essential for proper function of compartmentalized organisms, and tyrosine phosphorylation plays an important role in this process. We analyzed the impact of protein tyrosine phosphatase (PTP) inhibition on the structure of endothelial junctional
Erik H Christen et al.
Protein expression and purification, 66(2), 158-164 (2009-03-28)
Inducer-dependent prokaryotic transcriptional repressor proteins that originally evolved to orchestrate the transcriptome with intracellular and extracellular metabolite pools, have become universal tools in synthetic biology, drug discovery, diagnostics and functional genomics. Production of the repressor proteins is often limited due
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