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Merck

T1573

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

Synonym(s):

TRAP-6

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About This Item

Empirical Formula (Hill Notation):
C34H56N10O9
CAS Number:
141136-83-6
Molecular Weight:
748.87
NACRES:
NA.77
PubChem Substance ID:
329826680
UNSPSC Code:
12352200
MDL number:
MFCD00238172

Key Documents

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Product Name

Thrombin Receptor Activator Peptide 6, >95% (HPLC)

InChI key

HAGOWCONESKMDW-FRSCJGFNSA-N

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

assay

>95% (HPLC)

form

lyophilized

technique(s)

cell culture | mammalian: suitable

solubility

0.1% TFA: soluble
water: soluble

UniProt accession no.

P25116

storage temp.

−20°C

Quality Level

200

Gene Information

human ... F2R(2149)

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Biochem/physiol Actions

Hexapeptide fragment of the thrombin receptor (residues 42-47).
Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).

General description

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
118M4802V
117M4764V
23170712
027M4866V
086M4825V

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Saskia Wand et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 24(1), 179-185 (2017-03-18)
We aimed to identify the prevalence of acetylsalicylic acid (ASA) nonresponse in patients after coronary artery bypass graft (CABG) surgery and the possible consequences for the rate of major cardiovascular events. This prospective, observational, bicentric cohort study was conducted in
JCAD, a gene at the 10p11 coronary artery disease locus, regulates Hippo signaling in endothelial cells
Jones PD, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(8), 1711-1722 (2018)
Chemistry and Biology of Serpins (2012)
Juergen Koessler et al.
PloS one, 12(11), e0188193-e0188193 (2017-11-21)
Platelets are important for effective hemostasis and considered to be involved in pathophysiological processes, e.g. in cardiovascular diseases. Platelets provided for research or for therapeutic use are frequently separated from citrated whole blood (WB) stored for different periods of time.
Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis
Johnson KE, et al.
Blood advances, 3(2), 198-211 (2019)
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