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Merck

T1875

Testosterone propionate

solid

Synonym(s):

17β-Hydroxy-4-androsten-3-one 17-propionate, 17β-Propionyloxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one 17-propionate

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About This Item

Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
57-85-2
Molecular Weight:
344.49
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
24899994
EC Number:
200-351-1
Beilstein/REAXYS Number:
3221760
MDL number:
MFCD00003653
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200

Key Documents

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biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

acetone: soluble 1 in 4 of acetone, chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow, ethanol: soluble 1 in 6 of ethanol, ethyl oleate: soluble 1 in 20 of ethyl oleate, propylene glycol: soluble 1 in 30 of propylene glycol, soluble 1 in 20 of ethyl oleate, ethanol: 10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.4 mg/mL, H2O: insoluble, oil: soluble

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])OC(=O)CC

InChI

1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

InChI key

PDMMFKSKQVNJMI-BLQWBTBKSA-N

Gene Information

human ... AR(367), CYP17A1(1586)
rat ... Ar(24208)

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Application

Testosterone propionate has been used for studying its effects on pregnant ewes,.

Biochem/physiol Actions

Androgens direct the development of the male phenotype during embryogenesis and at puberty. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone in the target tissues where it regulates several biological functions. Testosterone propionate has been synthetically derived from a plant. This product has extended and faster-acting functions when compared to other testosterone esters.

Physical form

Photosensitive solid

Preparation Note

This product is soluble in chloroform (50 mg/ml). It is also soluble in various oils. The oil solutions can be sterilized by maintaining at 150 deg C for 1 hour. It is practically insoluble in water, soluble 1 in 6 of ethanol, 1 in 4 of acetone, 1 in 20 of ethyl oleate, and 1 in 30 of propylene glycol. The product is incompatible with alkalis and oxidizing agents and it should be protected from light.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T1875-BULK: + T1875-200G: + T1875-1G: + T1875-100G: + T1875-VAR: + T1875-5G:

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Tsuyoshi Shimmura et al.
Scientific reports, 9(1), 3978-3978 (2019-03-10)
Animals that communicate using sound are found throughout the animal kingdom. Interestingly, in contrast to human vocal learning, most animals can produce species-specific patterns of vocalization without learning them from their parents. This phenomenon is called innate vocalization. The underlying
Jean-Marc Israel et al.
Nature communications, 5, 3285-3285 (2014-02-13)
The pituitary gland releases hormones in a pulsatile fashion guaranteeing signalling efficiency. The determinants of pulsatility are poorly circumscribed. Here we show in magnocellular hypothalamo-neurohypophyseal oxytocin (OT) neurons that the bursting activity underlying the neurohormonal pulses necessary for parturition and
M E Rose et al.
Infection and immunity, 26(2), 630-637 (1979-11-01)
Comparisons were made between infections with Eimeria spp. in normal animals and in animals with functional deficiencies in either T-lymphocytes (athymic nude rats) or B-lymphocytes (bursectomized chickens). Approximately three times more oocysts of E. nieschulzi were passed during a primary
Maria Cernea et al.
Endocrinology, 156(9), 3277-3291 (2015-06-11)
Prenatal testosterone (T)-treated ewes display a constellation of reproductive defects that closely mirror those seen in PCOS women, including altered hormonal feedback control of GnRH. Kisspeptin/neurokinin B/dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in steroid
Francois Mougeot et al.
Proceedings. Biological sciences, 276(1659), 1093-1100 (2009-01-09)
Extravagant ornaments evolved to advertise their bearers' quality, the honesty of the signal being ensured by the cost paid to produce or maintain it. The oxidation handicap hypothesis (OHH) proposes that a main cost of testosterone-dependent ornamentation is oxidative stress
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