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Merck

U3003

Uridine

powder, BioReagent, suitable for cell culture

Synonym(s):

1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside

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About This Item

Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
58-96-8
Molecular Weight:
244.20
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24900638
EC Number:
200-407-5
Beilstein/REAXYS Number:
754902
MDL number:
MFCD00006526
Assay:
≥99%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: 50 mg/mL

Key Documents

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InChI key

DRTQHJPVMGBUCF-XVFCMESISA-N

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

biological source

synthetic (organic)

product line

BioReagent

assay

≥99%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

163-167 °C (lit.)

solubility

H2O: 50 mg/mL

Quality Level

200

Gene Information

mouse ... Uck1(22245)

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Application

Uridine has been used:
  • as an inhibitor of schwann cell proliferation in rat dorsal root ganglia (DRG) neurons culture
  • as a medium supplement for epiblasts culture
  • as a component of 5-fluoro-2′-deoxyuridine stock solution used for neuronal culture

Biochem/physiol Actions

Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. Uridine has numerous biological functions like, treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine induces insulin resistance.

General description

Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid. Uridine is a substrate for nucleotide synthesis in living organisms by de- novo and salvage pathways.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

U3003-50G: + U3003-VAR: + U3003-25G: + U3003-5G: + U3003-BULK: + U3003-500MG: + U3003-1G: + U3003-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6636
BCCG3081
BCCF9386
BCCF6136
BCCD9057

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Preparation of rat brain aggregate cultures for neuron and glia development studies
Koito H and Li J
Journal of Visualized Experiments, 22(31), 625-633 (2009)
Characterisation of bovine epiblast-derived outgrowth colonies
Oestrup E, et al.
Reproduction, Fertility, and Development, 22(4), 625-633 (2010)
Biochemistry of uridine in plasma
Yamamoto T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 412(19-20), 17121724-17121724 (2011)
Neurite outgrowth of dorsal root ganglia neurons is enhanced on aligned nanofibrous biopolymer scaffold with carbon nanotube coating
Jin GZ, et al.
Neuroscience Letters, 501(1), 10-14 (2011)
CAD mutations and uridine-responsive epileptic encephalopathy
Koch J, et al.
Brain, 140(2), 279286-279286 (2016)
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