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V116

Z-VAD-FMK

Name: Z-VAD-FMK
Brand: SIGMA

≥98% (TLC), solid, Caspase inhibitor

Synonym(s):

N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₃₀FN₃O₇

CAS Number:

187389-52-2

Molecular Weight:

467.49

UNSPSC Code:

12352209

NACRES:

NA.77

MDL number:

MFCD01074990

Assay:

≥98% (TLC)

Form:

solid

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Properties

Product Name

Z-VAD-FMK, solid

biological source

synthetic

Quality Segment

200

assay

≥98% (TLC)

form

solid

color

white

solubility

DMSO: 20 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC

InChI

1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

InChI key

MIFGOLAMNLSLGH-QOKNQOGYSA-N

Gene Information

human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)

Description

General description

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.

Application

Z-VAD-FMK has been used:

to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
to induce autophagy in Jurkat and K562 cells
to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

Biochem/physiol Actions

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Disclaimer

Hygroscopic

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

V116-VAR: + V116-2MG: + V116-BULK:

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