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この商品について
化学式:
H215N(13CH2)413CH(15NH2)13CO2H · HCl
CAS番号:
分子量:
190.59
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Isotopic purity:
99 atom % 13C, 99 atom % 15N
Assay:
95% (CP)
Mass shift:
M+8
Form:
solid
isotopic purity
99 atom % 13C, 99 atom % 15N
assay
95% (CP)
form
solid
optical activity
[α]25/D +20.7°, c = 2 in 5 M HCl
technique(s)
bio NMR: suitable, protein expression: suitable
mp
263-264 °C (dec.) (lit.)
mass shift
M+8
storage temp.
room temp
SMILES string
Cl.[15NH2][13CH2][13CH2][13CH2][13CH2][13C@H]([15NH2])[13C](O)=O
InChI
1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1;
InChI key
BVHLGVCQOALMSV-GSMNGUNQSA-N
関連するカテゴリー
General description
Lysine is a basic ketogenic amino acid with a protonated alkyl amino group. Lysine degradation results in the formation of acetoacetate. Acetylation/deacetylation of lysine residues in histones is a mechanism to regulate chromatin organization in eukaryotes. Isotope labeled amino acids are required for the production of isotopically labeled proteins.
Application
Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages.
- L-Lysine-13C6,15N2 hydrochloride has been used in pSILAC (pulsed stable isotope labeling by amino acids in cell culture) mass spectrometry to study protein profile in cells transfected with microRNAs.
- It has been used in SILAC isotopic labeling for the characterization of lysine racemase.
- It has been used in SILAC labeling for phosphoproteomic measurements in neuro-2a cells treated with and without GFKP-19 (2-pyrrolidone derivative).
Packaging
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Cell-specific labeling enzymes for analysis of cell-cell communication in continuous co-culture.
Tape CJ, et al.
Molecular and Cellular Proteomics, 13, 1866-1876 (2014)
Whole cell proteome regulation by microRNAs captured in a pulsed SILAC mass spectrometry approach.
Ebner OA and Selbach M
Methods in Molecular Biology, 725, 315-331 (2011)
Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells.
Yu C, et al.
Frontiers in Physiology, 7, 635-635 (2016)
Alex A Makarov et al.
Nature communications, 10(1), 3056-3056 (2019-07-13)
Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we
Roberto Ravasio et al.
Science advances, 6(15), eaax2746-eaax2746 (2020-04-15)
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of
関連コンテンツ
タンパク質構造解析は治療に欠かせない疾患バイオマーカーや薬物ターゲットの特定に役立ちます。
Protein structure analysis aids in identifying disease biomarkers and drug targets crucial for therapeutic treatments.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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