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695874

2-ジ-tert-ブチルホスフィノ-2′-(N,N-ジメチルアミノ)ビフェニル

solid

別名:

2′-(ジ-tert-ブチルホスフィノ)-N,N-ジメチルビフェニル-2-アミン, t-Butyl DavePhos, t-BuDavePhos, tBuDavePhos

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この商品について

実験式（ヒル表記法）:
C22H32NP
CAS番号:
224311-49-3
分子量:
341.47
UNSPSC Code:
12352116
PubChem Substance ID:
329761782
NACRES:
NA.22
MDL number:
MFCD03426986
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製品名

2-ジ-tert-ブチルホスフィノ-2′-(N,N-ジメチルアミノ)ビフェニル,

form

solid

Quality Level

100

reaction suitability

reagent type: ligand
reaction type: Arylations, reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: ligand
reaction type: C-X Bond Formation

mp

114-118 °C

functional group

phosphine

SMILES string

CN(C)c1ccccc1-c2ccccc2P(C(C)(C)C)C(C)(C)C

InChI

1S/C22H32NP/c1-21(2,3)24(22(4,5)6)20-16-12-10-14-18(20)17-13-9-11-15-19(17)23(7)8/h9-16H,1-8H3

InChI key

PHLPNEHPCYZBNZ-UHFFFAOYSA-N

Application

Buchwaldホスフィン配位子の詳細を確認する

ジアルキルビアリールホスフィン配位子は、さまざまな状況でPd触媒反応によく使用されます。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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試験成績書（COA）

Lot/Batch Number
00616PH

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資料

Buchwald Phosphine Ligands

Buchwald phosphine ligands for C-C, C-N, and C-O bond formation.

関連コンテンツ

Buchwald Portfolio - Precatalysts and Ligands

Buchwald Portfolio: Palladacycles and Ligands

Buchwald Group – Professor Product Portal

The Buchwald group has developed a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The ligands are electron-rich, and highly tunable to provide catalyst systems with a diverse scope, high stability and reactivity. Furthermore, the new series of precatalysts are air-, moisture and thermally-stable and display good solubility in common organic solvents. The use of precatalysts ensures the efficient generation of the active catalytic species and allows one to accurately adjust the ligand:palladium ratio. The ligands, precatalysts and methodology developed in the Buchwald group are user friendly and have rendered previously difficult cross couplings reactions, much easier to achieve.

Phosphine Ligand Application Guide

Phosphine Ligand Application Guide

David S Surry et al.
Chemical science, 2(1), 27-50 (2011-01-01)
Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions and have been applied in a range of contexts. This review attempts to aid the reader in the selection of the best choice of reaction conditions and ligand
Ruben Martin et al.
Accounts of chemical research, 41(11), 1461-1473 (2008-07-16)
The cores of many types of polymers, ligands, natural products, and pharmaceuticals contain biaryl or substituted aromatic structures, and efficient methods of synthesizing these structures are crucial to the work of a broad spectrum of organic chemists. Recently, Pd-catalyzed carbon-carbon
David S Surry et al.
Angewandte Chemie (International ed. in English), 47(34), 6338-6361 (2008-07-30)
Palladium-catalyzed amination reactions of aryl halides have undergone rapid development in the last 12 years, largely driven by the implementation of new classes of ligands. Biaryl phosphanes have proven to provide especially active catalysts in this context. This Review discusses