A4926
1,2-ビス(2-アミノフェノキシ)エタン-N,N,N′,N′-四酢酸
98%
別名:
2,2′-(エチレンジオキシ)ジアニリン-N,N,N′,N′-四酢酸, BAPTA, エチレンジオキシビス(o-フェニレンニトリロ)四酢酸
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この商品について
実験式（ヒル表記法）:
C22H24N2O10
CAS番号:
分子量:
476.43
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5192406
製品名
1,2-ビス(2-アミノフェノキシ)エタン-N,N,N′,N′-四酢酸, 98%
InChI
1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)
SMILES string
OC(=O)CN(CC(O)=O)c1ccccc1OCCOc2ccccc2N(CC(O)=O)CC(O)=O
InChI key
FTEDXVNDVHYDQW-UHFFFAOYSA-N
assay
98%
form
powder
storage temp.
2-8°C
Quality Level
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関連するカテゴリー
Application
Ca2+欠乏症の形態学的およびシグナル伝達の研究に使用されます。
General description
自然界では、1,2-ビス(2-アミノフェノキシ)エタン-N,N,N′,N′-テトラ酢酸（BAPTA）は、ラットにおける脳虚血の神経保護剤であるBAPTA-AM（BAPTA-テトラアセトキシメチルエステル）の主な代謝産物です。BAPTAは細胞間Ca2+キレート剤です。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Zheng Feng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(30), 3052-3058 (2010-10-23)
BAPTA free acid was identified as the main metabolic product of 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra(actoxymethyl ester) (BAPTA-AM), a neuroprotective agent in cerebral ischemia, in rats. In this paper, liquid chromatography-ultraviolet (LC-UV) and mass spectrometry/mass spectrometry (LC-MS/MS) methods were employed for the
Roger C Hardie
Cell calcium, 38(6), 547-556 (2005-09-06)
In vivo light-induced and basal hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC) were monitored in Drosophila photoreceptors using genetically targeted PIP2-sensitive ion channels (Kir2.1) as electrophysiological biosensors for PIP2. In cells loaded via patch pipettes with varying
K S Han et al.
Journal of neurochemistry, 78(2), 230-239 (2001-07-20)
Sustained alteration in [Ca(2+)]i triggers neuronal death. We examined morphological and signaling events of Ca(2+)-deficiency-induced neuronal death. Cortical cell cultures exposed to 20 microM 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA-AM), an intracellular calcium chelator, underwent neuronal apoptosis within 12 h that was evident
Mayeul Collot et al.
Journal of the American Chemical Society, 134(36), 14923-14931 (2012-07-24)
We designed Calcium Rubies, a family of functionalizable BAPTA-based red-fluorescent calcium (Ca(2+)) indicators as new tools for biological Ca(2+) imaging. The specificity of this Ca(2+)-indicator family is its side arm, attached on the ethylene glycol bridge that allows coupling the
Alexander M Walter et al.
The EMBO journal, 33(15), 1681-1697 (2014-06-07)
The SNARE protein vti1a is proposed to drive fusion of intracellular organelles, but recent data also implicated vti1a in exocytosis. Here we show that vti1a is absent from mature secretory vesicles in adrenal chromaffin cells, but localizes to a compartment
資料
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
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