製品名
17:0-20:4 PI(3,4,5)P3, Avanti Research™ - A Croda Brand
form
powder
manufacturer/tradename
Avanti Research™ - A Croda Brand
packaging
1 ea of 1 × (with stopper and crimp cap (LM1906-1EA))
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP(O)([O-])=O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+].[NH4+]
InChI
1S/C46H84O22P4.4H3N/c1-3-5-7-9-11-13-15-17-19-20-21-23-25-27-29-31-33-35-40(48)64-38(36-62-39(47)34-32-30-28-26-24-22-18-16-14-12-10-8-6-4-2)37-63-72(60,61)68-43-41(49)44(65-69(51,52)53)46(67-71(57,58)59)45(42(43)50)66-70(54,55)56;;;;/h11,13,17,19,21,23,2
InChI key
FSWQCDGXUXSIRI-VHLOILQVSA-N
General description
ホスファチジルイノシトール-3,4,5-三リン酸［PI(3,4,5)P3］は、細胞膜、細胞内部位、核に局在しています。
Application
17:0-20:4 PI(3,4,5)P3［別名：1-ヘプタデカノイル-2-(5Z,8Z,11Z,14Z-エイコサテトラエノイル)-sn-グリセロ-3-ホスホ-(1′-ミオ-イノシトール-3′,4′,5′-三リン酸］は以下の用途に用いられています。
- 超高速液体クロマトグラフィー-タンデム質量分析（UPLC/MS）の脂質標準として
- Drosophila（ショウジョウバエ）幼虫組織からの脂質抽出の内部標準として
- メチル化ホスファチジルイノシトールリン酸（PIP）の液体クロマトグラフィー-タンデム質量分析（LC-MS/MS）の内部標準として
Biochem/physiol Actions
ホスファチジルイノシトール-3,4,5-三リン酸［PI(3,4,5)P3］は、タンパク質の活性化に関与しています。いくつかの細胞プロセスにとって重要なシグナル分子であり、セカンドメッセンジャーとして機能します。PI(3,4,5)P3は、ヒトの病気の原因とも関わりがあります。
Packaging
2 mL琥珀色血清バイアル、栓および波形キャップ付き（LM1906-1EA）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
保管分類
11 - Combustible Solids
Prasenjit Manna et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1253-1275 (2015-02-28)
Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P₃) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains. Localization and activation of these effector proteins regulate a number of cellular functions
Yvonne Lindsay et al.
Journal of cell science, 119(Pt 24), 5160-5168 (2006-12-13)
Phosphatidylinositol (3,4,5) trisphosphate [PtdIns(3,4,5)P3] is a lipid second messenger, produced by Type I phosphoinositide 3-kinases (PI 3-kinases), which mediates intracellular responses to many growth factors. Although PI 3-kinases are implicated in events at both the plasma membrane and intracellular sites
Sanjeev Sharma et al.
Cell reports, 27(7), 1979-1990 (2019-05-16)
Phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor required for normal growth and metabolism. We report that in Drosophila, phosphatidylinositol 5 phosphate 4-kinase (PIP4K) is