M-132
N-メチル-N-(トリメチルシリル)トリフルオロアセトアミド
ampule of 10 × 1.2 mL, analytical standard, Cerilliant®
別名:
N-トリメチルシリル-N-メチルトリフルオロアセトアミド, MSTFA
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この商品について
化学式:
CF3CON(CH3)Si(CH3)3
CAS番号:
分子量:
199.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
InChI key
MSPCIZMDDUQPGJ-UHFFFAOYSA-N
InChI
1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
SMILES string
CN(C(=O)C(F)(F)F)[Si](C)(C)C
grade
analytical standard
vapor density
>1 (vs air)
vapor pressure
8.8 mmHg ( 27 °C)
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
packaging
ampule of 10 × 1.2 mL
manufacturer/tradename
Cerilliant®
technique(s)
gas chromatography (GC): suitable
refractive index
n20/D 1.38 (lit.)
bp
130-132 °C (lit.)
density
1.075 g/mL at 25 °C (lit.)
application(s)
forensics and toxicology
format
neat
storage temp.
−20°C
Quality Level
General description
MSTFA (N-Methyl-N-trimethylsilylfluoroacetamide) is an important trimethylsilyl reagent, and a commonly applied reagent since it is highly reactive towards a broad range of compound classes. GC-MS optimization studies reveal the use of this reagent either alone or in combination with 1% of trimethylchlorosilane as a catalyst for silylation of complex mixtures. It has similar reactivity as BSA and BSTFA.
Application
MSTFA reagent may be used as a derivatizing agent in the following:
- Analysis of estrogen steroids such as estrone (E1), 17α-ethinylestradiol (EE2), and trenbolone acetate metabolites, melengestrol in environmental matrices using gas chromatography coupled to mass spectrometry (GC-MS).
- Quantification of ibuprofen, naproxen, ketoprofen, and diclofenac in wastewater samples using gas chromatography coupled to mass spectrometry (GC-MS).
Features and Benefits
- Very volatile of TMS-acetamides.
- More volatile than BSA or BSTFA but with similar silylation strength.
- Useful in the analysis of volatile trace materials.
- Used in the preparation of volatile and thermally stable derivatives for GC and MS analysis.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
3 - Flammable liquids
wgk
WGK 3
flash_point_f
77.0 °F - closed cup
flash_point_c
25 °C - closed cup
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
第4類:引火性液体 + 第二石油類 + 危険等級III + 非水溶性液体
fsl
M-132-10X1.2ML:
jan
The use of trimethylsilyl cyanide derivatization for robust and broad-spectrum high-throughput gas chromatography?mass spectrometry based metabolomics
Khakimov B, et al.
Analytical and Bioanalytical Chemistry, 405(3), 9193-9205 (2013)
Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry
Sebok A, et al.
Talanta, 76(3), 642-650 (2008)
Guro Forsdahl et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 811(2), 201-208 (2004-11-04)
This paper describes a gas chromatography (GC)--mass spectrometry (MS) method for the simultaneous quantification of ephedrine, pseudoephedrine, cathine, norephedrine and methylephedrine in urine. The sample preparation step includes solid phase extraction and derivatisation with N-methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA). An evaluation of various
John A Bowden et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3237-3242 (2009-08-21)
Steroid derivatization was investigated by varying the experimental parameters (reagent, reaction time, and reaction temperature) to determine the optimal conditions for individual steroids, and for larger subsets. Three methods of derivatization enhancement were also investigated: the use of sonication, the
Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
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