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05-23-0101

Angiotensin II, Human

Name: Angiotensin II, Human
Brand: MM

Plays an important role in the regulation of blood pressure.

別名:

Angiotensin II, Human, DRVYIHPF, ang II

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この商品について

実験式（ヒル表記法）:

C₅₀H₇₁N₁₃O₁₂

CAS番号:

4474-91-3

分子量:

1046.18

UNSPSC Code:

12352202

NACRES:

NA.77

eCl@ss:

42020611

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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特性

biological source

human

Quality Level

100

sterility

non-sterile

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

technique(s)

cell based assay: suitable

color

white to off-white

solubility

5% acetic acid: 1 mg/mL, water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Gene Information

human ... ACE2(59272)

詳細

General description

Research area: Cell signaling

Cell permeable: no

Primary Target adenylate cyclase activity

Product does not compete with ATP.

Reversible: no

Application

Angiotensin II, Human has been used to induce fibrosis in mice to evaluate the impact of fibroblast loss on cardiac function after injury. It has also been used to induce abdominal aortic aneurysm (AAA) progression in mice.

Biochem/physiol Actions

Angiotensin II is a crucial component of the Renin-Angiotensin System (RAS). It plays a vital role in vasoconstriction, regulating blood pressure, and controlling fluid balance by influencing the retention of sodium and water in the renal tubules. Furthermore, Angiotensin II stimulates the release of aldosterone from the adrenal gland, contributing to the maintenance of fluid and electrolyte balance regulation. Angiotensin II also promotes inflammation and tissue injury. It Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II also activates JAK2 in smooth muscle cells, as well as several kinases including p125FAK, cytosolic calcium-dependent tyrosine kinase, and p60c-src in various cell types. In vascular smooth muscle cells, it activates ERK1/2, JNK, and p38 MAP Kinase.

Packaging

Yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Other Notes

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Zhu, M., et al. 2000. J. Neurophysiol.84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c