07-013
Anti-MeCP2 Antibody
Upstate®, from rabbit
別名:
MeCP-2 protein, mental retardation, X-linked 16, mental retardation, X-linked 79, methyl CpG binding protein 2, methyl CpG binding protein 2 (Rett syndrome)
製品名
Anti-MeCP2 Antibody, Upstate®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, mouse
packaging
antibody small pack of 25 μg
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Mecp2(17257)
rat ... Mecp2(29386)
関連するカテゴリー
Analysis Note
Control
Mouse Brain lysate.
Mouse Brain lysate.
Evaluated by Western Blot on Mouse Brain lysates.
Application
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Use Anti-MeCP2 Antibody (rabbit polyclonal antibody) validated in WB to detect MeCP2 also known as MeCP-2 protein, mental retardation X-linked 16, mental retardation X-linked 79, methyl CpG binding protein 2.
Biochem/physiol Actions
Predicted to cross-react with human based on the conservation of the immunogenic sequence.
Recognizes MeCP2, Mr 75 kDa. A protein at ~75 kDa was also observed in HeLa nuclear extract. This protein was competed by pre-incubation of the antibody with the immunogenic peptide, suggesting that some HeLa strains contain MeCP2 or a related protein, contrary to a previous report.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
NA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X chromosome inactivation. Methyl CpG binding proteins (MeCPs) specifically recognize methylated regions of DNA and repress transcription both directly and by association with known corepressor proteins which include members of the histone deacetylase protein families.
~75 kDa observed
Immunogen
KLH-conjugated, synthetic peptide corresponding to amino acids 465-478 of mouse MeCP2 (C-PRPNREEPVDSRTP) with an N-terminal cysteine added for conjugation purposes.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein A purified
Purified rabbit polyclonal IgG in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome.
Jan P Buschdorf, Wolf H Stratling
Journal of Molecular Medicine null
MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome.
M Wan, K Zhao, S S Lee, U Francke
Human Molecular Genetics null
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.
Fuks, F; Hurd, PJ; Wolf, D; Nan, X; Bird, AP; Kouzarides, T
The Journal of Biological Chemistry null
SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta.
Lin, Q; Chen, D; Timchenko, NA; Medrano, EE
Cell Cycle null
Ocular MECP2 protein expression in patients with and without Rett syndrome.
Jain D, Singh K, Chirumamilla S, Bibat GM, Blue ME, Naidu SR, Eberhart CG
Pediatric Neurology null
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 07-013 | 04053252585944 |
| 07-013-25UG | 04054839342479 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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