07-546
Anti-ADAP/SLAP-130/Fyb Antibody
Upstate®, from rabbit
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この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
10
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FYB(2533)
General description
130kDa
Immunogen
synthetic peptide corresponding to amino acids 755-768 of mouse Fyn binding protein (ADAP/SLAP-130/Fyb)
Application
Anti-ADAP/SLAP-130/Fyb Antibody is an antibody against ADAP/SLAP-130/Fyb for use in WB & IP.
Research Category
Signaling
Signaling
Research Sub Category
Immunological Signaling
Kinases & Phosphatases
Immunological Signaling
Kinases & Phosphatases
Biochem/physiol Actions
ADAP/SLAP-130/Fyb
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A purified
Preparation Note
2 years at -20°C
Analysis Note
routinely evaluated by immunoblot in RIPA lysates from RAW 264.7 macrophage cells
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
wgk
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
07-546:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Rajasekaran, K; Kumar, P; Schuldt, KM; Peterson, EJ; Vanhaesebroeck, B; Dixit, V; Thakar et al.
Nature Immunology null
A J Hunter et al.
Journal of immunology (Baltimore, Md. : 1950), 164(3), 1143-1147 (2000-01-21)
The role of integrin-mediated signaling events in T cell function remains incompletely characterized. We report here that alpha4beta1 integrin stimulation of H9 T cells and normal human T cell blasts results in rapid and transient tyrosine phosphorylation of the adapter
L Geng et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(20), 11527-11532 (2001-09-13)
Aggregation of the high-affinity IgE receptor (FcepsilonRI) on mast cells activates a tyrosine phosphorylation cascade that is required for adhesion and degranulation events leading to the release of histamine and other inflammatory mediators. The full range of intracellular mediators that
N J Boerth et al.
The Journal of biological chemistry, 275(7), 5143-5152 (2000-02-15)
T cell antigen receptor (TCR) engagement results in protein-tyrosine kinase activation which initiates signaling cascades leading to induction of the interleukin-2 gene. Previous studies identified two substrates of the TCR-induced protein-tyrosine kinases, SH2 domain-containing leukocyte specific protein of 76 kDa
Chunyang Li et al.
EMBO molecular medicine, 7(6), 754-769 (2015-04-09)
PD-1 negatively regulates CD8(+) cytotoxic T lymphocytes (CTL) cytotoxicity and anti-tumor immunity. However, it is not fully understood how PD-1 expression on CD8(+) CTL is regulated during anti-tumor immunotherapy. In this study, we have identified that the ADAP-SKAP55 signaling module
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 07-546 | 04053252670336 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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