203293
Bisindolylmaleimide I
InSolution, ≥95%, protein kinase C (PKC) inhibitor
別名:
InSolution Bisindolylmaleimide I, 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850
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この商品について
実験式（ヒル表記法）:
C25H24N4O2
CAS番号:
分子量:
412.48
UNSPSC Code:
12352111
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
shipped in
wet ice
storage temp.
−20°C
SMILES string
N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)cccc3
InChI
1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChI key
QMGUOJYZJKLOLH-UHFFFAOYSA-N
General description
A highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα, βI, βII, γ, δ, and ε isozymes. May inhibit protein kinase A at a much higher concentration (Ki = 2 µM). Also inhibits telomerase A treated NPC-076 cells. A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKC
PKC
Product competes with ATP.
Reversible: yes
Target Ki: 10 nM against PKC
Packaging
Packaged under inert gas
Physical form
A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun.241, 730.
Gekeler, V., et al. 1996. Br. J. Cancer74, 897.
Kiss, Z., et al. 1995. Biochim. Biophys. Acta1265, 93.
Muid, R.E., et al. 1991. FEBS Lett.293, 160.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.
Gekeler, V., et al. 1996. Br. J. Cancer74, 897.
Kiss, Z., et al. 1995. Biochim. Biophys. Acta1265, 93.
Muid, R.E., et al. 1991. FEBS Lett.293, 160.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - (refers to pure substance)
flash_point_c
87 °C - (refers to pure substance)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water insoluble liquid
fsl
203293-1ML:
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