421050
(Z-LL)2 Ketone
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.
別名:
(Z-LL)2 Ketone, 1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
製品名
(Z-LL)2 Ketone, A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Analysis Note
single spot by TLC
Biochem/physiol Actions
Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide
Processing of the p-Prl signal peptide
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 50 nM inhibiting the processing of the p-Prl signal peptide
Disclaimer
Toxicity: Standard Handling (A)
General description
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
Other Notes
Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Youngkyung Cho et al.
BMC biology, 18(1), 60-60 (2020-06-05)
Epithin/PRSS14, a type II transmembrane serine protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis. In many circumstances, the protease, through its ectodomain shedding, exists as a soluble form and performs
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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