475880
ML-7 Hydrochloride
>98% (TLC), protein kinase A and C inhibitor, solid
別名:
ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
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この商品について
実験式（ヒル表記法）:
C15H17IN2O2S · xHCl
CAS番号:
分子量:
416.28 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
製品名
ML-7, Hydrochloride, A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).
SMILES string
Ic1c2c(c(ccc2)[S](=O)(=O)N3CCNCCC3)ccc1
InChI
1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
InChI key
GEHJIACZUFWBTK-UHFFFAOYSA-N
assay
>98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
50% ethanol: 4.5 mg/mL
DMSO: 4.5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Myosin light chain kinase (Mlck)
Myosin light chain kinase (Mlck)
Product competes with ATP.
Reversible: yes
Target Ki: 300 nM against myosin light chain kinase
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.
Other Notes
Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Further dilute with aqueous buffer just prior to use.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Journal of cell science, 135(10) (2022-05-28)
Podosomes are mechanosensitive protrusive actin structures that are prominent in myeloid cells, and they have been linked to vascular extravasation. Recent studies have suggested that podosomes are hierarchically organized and have coordinated dynamics on the cell scale, which implies that
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PLoS pathogens, 18(3), e1010309-e1010309 (2022-03-23)
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Hélène Doerflinger et al.
Current biology : CB, 32(2), 374-385 (2021-12-03)
The Drosophila anterior-posterior axis is specified at mid-oogenesis when the Par-1 kinase is recruited to the posterior cortex of the oocyte, where it polarizes the microtubule cytoskeleton to define where the axis determinants, bicoid and oskar mRNAs, localize. This polarity
Mitchell J George et al.
International journal of molecular sciences, 22(12) (2021-07-03)
Myosin Light Chain (MLC) regulates platelet contraction through its phosphorylation by Myosin Light Chain Kinase (MLCK) or dephosphorylation by Myosin Light Chain Phosphatase (MLCP). The correlation between platelet contraction force and levels of MLC phosphorylation is unknown. We investigate the
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 475880-1MGCN | 04055977203493 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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