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5.06130

Reserpine

Name: Reserpine
Brand: MM

別名:

Reserpine, VMAT2 Inhibitor, Reserpine, Vesicular monoamine transporter (VMAT) Antagonist, Reserpine

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この商品について

実験式（ヒル表記法）:

C₃₃H₄₀N₂O₉

CAS番号:

50-55-5

分子量:

608.68

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00005091

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特性

assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 100 mM

storage temp.

2-8°C

SMILES string

N21[C@H](C[C@H]5[C@@H](C2)C[C@H]([C@@H]([C@H]5C(=O)OC)OC)OC(=O)c6cc(c(c(c6)OC)OC)OC)c3[nH]c4c(c3CC1)ccc(c4)OC

InChI

1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1

InChI key

QEVHRUUCFGRFIF-MDEJGZGSSA-N

詳細

General description

Binds the vesicular monoamine transporter (VMAT2) and acts as an irreversible transport inhibitor of biogenic amines. Used as a long-lasting bioamine depleter. Prevents bioamine transport into synaptic vesicles and chromaffin granules. Used as antihypertensive and antipsychotic drugs.

Biochem/physiol Actions

Primary Target
VMAT2

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Oe, T., et al. 2010. Neurosci.169, 1860.
Metzger, R. et al. 2002. Eur. J. Pharmacol.456, 39.
Heslop, E., et al. 1999. Neuropharmacol.38, 883.
Schuldiner, S., et al. 1993. J. Biol. Chem.268, 29.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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signalword

Danger

pcodes

P202 - P261 - P264 - P271 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3

target_organs

Central nervous system

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c