554325
Resveratrol
≥98% (HPLC), solid, COX-1 inhibitor, Calbiochem®
別名:
Resveratrol, trans-3,4ʹ,5-Trihydroxystilbene
製品名
Resveratrol, A phenolic product found in both grape skins and wines.
SMILES string
Oc1cc(cc(c1)\C=C\c2ccc(cc2)O)O
InChI
1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
InChI key
LUKBXSAWLPMMSZ-OWOJBTEDSA-N
description
Merck USA index - 14, 8158
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
ED50 = 15 µM against COX-1
Primary Target
COX-1
COX-1
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Other Notes
Howitz, K.T., et al. 2003. Nature425, 191.
Lin, H.Y., et al. 2002. J. Urol.168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.
Lin, H.Y., et al. 2002. J. Urol.168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
>392.0 °F - closed cup - (External MSDS)
flash_point_c
> 200.0 °C - closed cup - (External MSDS)
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Paulina Borkowska et al.
Life (Basel, Switzerland), 12(9) (2022-09-24)
The main problem with using MSC (mesenchymal stem cells) to treat the deficient diseases of the central nervous system is the low cell survival rate after the transplant procedure and their low ability to spontaneously differentiate into functional neurons. The
Oluwamolakun Bankole et al.
International journal of molecular sciences, 23(3) (2022-02-16)
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder. There is no cure and current treatments fail to slow the progression of the disease. Epigenetic modulation in the acetylation state of NF-kB RelA and the histone 3 (H3) protein
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 554325-25MGCN | 04055977193053 |
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